PMID: 9436863Jan 22, 1998Paper

Increased prevalence of abnormal immunoglobulin M, G, and A concentrations at clinical onset of insulin-dependent diabetes mellitus: a registry-based study. The Belgian Diabetes Registry

Pancreas
F K GorusD G Pipeleers

Abstract

In view of the reported association of insulin-dependent diabetes mellitus (IDDM) with viral infections, (non-) islet-specific immune changes, and partial immunodeficiencies, we used immunonephelometry to measure circulating levels of IgM, IgG, and IgA in a registry-based group of IDDM patients under age 40 years at clinical onset (n = 397) and in age-matched nondiabetic siblings (n = 316) and control subjects (n = 322). Overall, IgM and IgA concentrations were higher, and IgG concentrations lower, in patients than in control subjects or siblings (P < 0.001). In siblings, IgM concentrations were higher than in control subjects (P < 0.001). Using age-adjusted reference intervals, abnormal Ig concentrations were noted in 27% of the patients at onset versus only 10% of the siblings and 7% of the control subjects (P < 0.001). For onset between 20 and 40 years (n = 220), 30% of the patients presented either increased IgM levels (21%) or decreased IgG levels (11%). Both independent phenomena occurred regardless of diabetes-associated immune and genetic markers. In patients and siblings, IgM levels were positively correlated with pancreatic lipase activity. In diabetic children (0-9 years; n = 65), a subgroup presented increased IgA l...Continue Reading

Citations

Jun 1, 2016·Diabetes Research and Clinical Practice·Xiaoyan GuoKaijun Niu
Nov 4, 2016·World Journal of Pediatrics : WJP·Styliani GizaAssimina Galli-Tsinopoulou
Jul 27, 2017·Pediatric Diabetes·Anna ParkkolaUNKNOWN Finnish Pediatric Diabetes Register
May 22, 2002·Annals of the New York Academy of Sciences·R Palanivel, D Sakthisekaran
Aug 30, 2020·The Journal of Clinical Endocrinology and Metabolism·Juan HuangLi Wen

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