Increased prevalence of acromegaly in a highly polluted area

European Journal of Endocrinology
S CannavòF Trimarchi

Abstract

Despite the contribution of national registries and population-based reports, data concerning the epidemiology of acromegaly is scanty. In addition, the role of the environmental context has not been investigated. Epidemiology of acromegaly was studied in the province of Messina (Sicily, Italy), focusing on the influence of environmental factors. Four zones, characterized by different degrees of exposition to environmental toxins due to industrial pollution, were identified in the province: area A (76,338 inhabitants), area B (287,328 inhabitants), area C (243,381 inhabitants), and area D (47,554 inhabitants) at low, middle-low, middle, and high industrial density respectively. We identified all acromegalics who were born and resided in the province of Messina, among patients either referred to our endocrine unit or referred elsewhere but recorded in the archives of the provincial healthcare agency. In the province of Messina, we found 64 patients (2 in area A, 24 in area B, 28 in area C, and 10 in area D). Macroadenomas were 60%, the male/female ratio was 1, and mean age at diagnosis (±s.e.m.) was 45.4±1.6 years. Overall, prevalence was 97 c.p.m. in the province (26 c.p.m. in area A, 84 c.p.m. in area B, 115 c.p.m. in area C, ...Continue Reading

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Citations

Oct 4, 2013·European Journal of Endocrinology·Etienne DelgrangeDominique Maiter
Jun 29, 2013·Pituitary·Maria Luisa TorreSalvatore Cannavo
Dec 3, 2015·Journal of Medical Economics·J J ZhangM P Neary
Oct 4, 2015·Clinical Endocrinology·Nunzia PrencipeSilvia Grottoli
Dec 19, 2012·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Gemma Sesmilo
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Apr 19, 2011·Orvosi hetilap·Zsuzsanna ValkuszJános Julesz
Apr 19, 2011·Orvosi hetilap·Judit DénesMiklós Góth
May 10, 2016·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Enrique López GavilanezEduardo Marriott Díaz
Apr 16, 2016·Endocrine-related Cancer·Anne-Lise LecoqPeter Kamenicky
Oct 8, 2016·Orphanet Journal of Rare Diseases·Thierry Brue, Frederic Castinetti
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