Increased prevalence of anxiety-associated personality traits in patients with Cushing's disease: a cross-sectional study

Neuroendocrinology
C DimopoulouC Sievers

Abstract

Chronic hypercortisolism in Cushing's disease (CD) has been suggested to contribute to an altered personality profile in these patients. We aimed to test this hypothesis and attempted to determine the effects of disease- and treatment-related factors that might moderate an altered personality in CD. We assessed 50 patients with CD (74% biochemically controlled) and compared them to 60 patients with non-functioning pituitary adenomas (NFPA) and 100 age- and gender-matched mentally healthy controls. Personality was measured by two standardized personality questionnaires, TPQ (Cloninger personality questionnaire) and EPQ-RK (Eysenck personality questionnaire-RK). Compared to mentally healthy controls, CD patients reported significantly less novelty-seeking behaviour, including less exploratory excitability and less extravagance. On harm avoidant subscales, they presented with more anticipatory worries and pessimism, higher fear of uncertainty, shyness with strangers, fatigability and asthenia. Moreover, CD patients appeared to be less extraverted, more neurotic and socially desirable. CD patients differed from NFPA patients in terms of higher neuroticism scores, and NFPA patients did not show altered novelty-seeking behaviour or e...Continue Reading

Citations

Aug 15, 2014·European Journal of Endocrinology·C DimopoulouC Sievers
Feb 24, 2016·Frontiers in Neuroscience·Scott J MoellerEliza B Geer
Nov 5, 2015·Nature·Avishek AdhikariKarl Deisseroth
Mar 21, 2015·European Journal of Endocrinology·Sarah M LeistnerCaroline Sievers
Jan 13, 2015·Pituitary·Georgia NtaliNiki Karavitaki
May 18, 2016·Endocrine·Rosario PivonelloAnnamaria Colao
Jan 11, 2020·Frontiers in Endocrinology·Alicia SantosSusan M Webb
Jun 30, 2019·Neurosurgical Review·Marta PertichettiFrancesco Doglietto

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