Increased prevalence of autoantibodies in celiac disease

Digestive Diseases and Sciences
A LernerY Shoenfeld

Abstract

Several features suggest an immune mechanism operates in celiac disease. Information on the autoantibody repertoire in this condition is lacking. The purpose of the study was to investigate the reactivity of celiac patients sera to various autoantigens widely distributed in the human intestine. Seventy children, celiacs and controls, were evaluated for serum autoantibodies using ELISA and immunofluorescence. Celiac patients had increased prevalence of serum anti-single-stranded DNA (14%), anti-double-stranded DNA (23%), anti-cardiolipin (14%), and anti-endomysial autoantibodies (63%). The relevance of this finding on the extraintestinal manifestations of celiac disease or the coexistence of autoimmune conditions and celiac disease remains to be determined.

Citations

Nov 4, 2000·Pediatrics International : Official Journal of the Japan Pediatric Society·H DemirF Gürakan
Apr 24, 2001·The American Journal of Gastroenterology·M J RenschS Kadakia
Sep 17, 2005·International Journal of Immunogenetics·S R da Rosa UtiyamaI T de Messias Reason
Feb 24, 2007·Digestive Diseases and Sciences·Sami KarouiAzza Filali
Jan 1, 2011·Case Reports in Gastrointestinal Medicine·Erwin BieckerMichael Schepke
Aug 22, 2018·Nutrients·Xuechen B YuArmin Alaedini
Apr 14, 1999·The American Journal of Gastroenterology·S IltanenM Mäki
May 1, 2002·European Journal of Gastroenterology & Hepatology·Aaron Lerner, Yehuda Shoenfeld
Aug 31, 2002·Endocrine Reviews·Pekka CollinJorma Salmi
Sep 1, 2001·Immunology·A Di SabatinoG R Corazza
Jun 12, 2003·World Journal of Gastroenterology : WJG·Giorgio La VillaGiacomo Laffi
Nov 27, 2007·Rheumatology International·Paola CaramaschiDomenico Biasi
Apr 29, 1999·Scandinavian Journal of Immunology·N LahatA Lerner
Jan 8, 2008·Autoimmunity·Armin Alaedini, Peter H R Green
Jan 6, 2001·Journal of Pediatric Gastroenterology and Nutrition·I R Korponay-SzabóM Mäki
Dec 29, 2015·Journal of Gastroenterology and Hepatology·Patompong UngprasertPansakorn Tanratana
Apr 6, 2013·BMC Medicine·Aaron LernerYehuda Shoenfeld
Jan 29, 2008·Journal of Clinical Gastroenterology·Hugh J Freeman
Jun 17, 2015·Pediatrics·Yekaterina ShermanThomas J A Lehman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.