Increased prevalence of cardiovascular disease in Type 2 diabetic patients with non-alcoholic fatty liver disease

Diabetic Medicine : a Journal of the British Diabetic Association
G TargherG Falezza

Abstract

To estimate the prevalence of cardiovascular disease (CVD) in Type 2 diabetic patients with and without non-alcoholic fatty liver disease (NAFLD), and to assess whether NAFLD is independently related to prevalent CVD. We studied 400 Type 2 diabetic patients with NAFLD and 400 diabetic patients without NAFLD who were matched for age and sex. Main outcome measures were prevalent CVD (as ascertained by medical history, physical examination, electrocardiogram and echo-Doppler scanning of carotid and lower limb arteries), NAFLD (by ultrasonography) and presence of the metabolic syndrome (MetS) as defined by the World Health Organization or Adult Treatment Panel III criteria. The prevalences of coronary (23.0 vs. 15.5%), cerebrovascular (17.2 vs. 10.2%) and peripheral (12.8 vs. 7.0%) vascular disease were significantly increased in those with NAFLD as compared with those without NAFLD (P < 0.001), with no differences between sexes. The MetS (by any criteria) and all its individual components were more frequent in NAFLD patients (P < 0.001). In logistic regression analysis, male sex, age, smoking history and MetS were independently related to prevalent CVD, whereas NAFLD was not. The prevalence of CVD is increased in patients with Typ...Continue Reading

References

Apr 18, 2001·Diabetes/metabolism Research and Reviews·G BrunoG Pagano
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
Aug 29, 2002·Gastroenterology·Sherif SaadehMichael J Sheridan
Dec 3, 2002·The American Journal of Cardiology·Daniel H O'Leary, Joseph F Polak
Dec 4, 2002·JAMA : the Journal of the American Medical Association·Hanna-Maaria LakkaJukka T Salonen
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni MussoGianfranco Pagano
Jun 24, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·UNKNOWN DAI Study Group
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jason M HuiJacob George
Aug 17, 2004·The American Journal of Gastroenterology·Naga ChalasaniDavid W Crabb
Oct 7, 2004·Clinics in Liver Disease·Stephen A Harrison, Brent A Neuschwander-Tetri
Jan 22, 2005·Annual Review of Medicine·David E Moller, Keith D Kaufman
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Angel BreaEmilio Ros
Mar 29, 2005·World Journal of Gastroenterology : WJG·Henry VolzkeUlrich John
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Jun 28, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nicola VillanovaGiulio Marchesini
Jul 2, 2005·Current Opinion in Lipidology·Giulio MarchesiniElisabetta Bugianesi
Sep 22, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni Targher
Jun 17, 2006·Minerva cardioangiologica·G Marchesini, M Babini

❮ Previous
Next ❯

Citations

Sep 4, 2012·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·Sergio NeriR Noto
May 13, 2011·Metabolic Syndrome and Related Disorders·Giorgio SoardoLeonardo A Sechi
Mar 13, 2012·European Heart Journal·Lokpal S BhatiaChristopher D Byrne
Dec 16, 2010·Journal of Gastroenterology and Hepatology·Jayani ManchanayakeGeoffrey C Farrell
Jun 30, 2009·Journal of Translational Medicine·Corrado LodigianiLidia Luciana Rota
Mar 14, 2008·The Review of Diabetic Studies : RDS·Atoosa AdibiMasoud Amini
Sep 8, 2010·World Journal of Gastroenterology : WJG·Mohamed-H Ahmed, Christopher-D Byrne
Sep 28, 2010·World Journal of Gastroenterology : WJG·Yu-Tao Zhan, Wei An
Mar 20, 2010·Mediators of Inflammation·Elizabeth HijonaLuis Bujanda
Mar 26, 2008·Journal of Endocrinological Investigation·G ForlaniG Marchesini
Oct 6, 2009·Journal of Gastroenterology·Claudio CaralloFrancesco Scopelliti
Sep 12, 2007·Digestive Diseases and Sciences·Kaz JaskiewiczZbigniew Sledzinski
Jun 10, 2011·Digestive Diseases and Sciences·W NseirN Assy
Dec 20, 2007·Endocrine Research·Leon A Adams
Apr 9, 2009·Annals of Medicine·Rafeeq Ali, Kenneth Cusi
Mar 6, 2012·The Kaohsiung Journal of Medical Sciences·Chia-Chi WangJia-Horng Kao
Jul 25, 2012·Clinics in Liver Disease·Mangesh R Pagadala, Arthur J McCullough
Sep 13, 2011·Diabetes Research and Clinical Practice·Hyun Il SeoWook Jin
Dec 26, 2015·Journal of Medical Ultrasonics·Hasan ÖztürkZeki Yüksel Günaydın
Oct 13, 2009·Clinics in Liver Disease·Anjana A Pillai, Mary E Rinella
May 16, 2009·Clinics in Liver Disease·Nila Rafiq, Zobair M Younossi
Dec 4, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nila RafiqZobair M Younossi
Apr 4, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Nathalie C LeiteClaudia R L Cardoso
Dec 10, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Raj Vuppalanchi, Naga Chalasani
Jul 16, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David van der PoortenJacob George
Jun 10, 2014·Journal of Gastroenterology and Hepatology·Jae-Hong RyooSung Keun Park
Mar 4, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David J HarmanGuruprasad P Aithal
Dec 15, 2010·Journal of Hepatology·Cristina RipollRafael Bañares
Jul 9, 2011·Journal of the American College of Cardiology·Zankhana RavalJames D Flaherty
May 31, 2016·Metabolism: Clinical and Experimental·Niki KatsikiChristos S Mantzoros
Dec 18, 2013·La Presse médicale·Habib Ben AhmedFaika Ben Mami Ben Miled

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.