PMID: 15232362Jul 3, 2004Paper

Increased prevalence of cholelithiasis in Gaucher disease: association with splenectomy but not with gilbert syndrome

Journal of Clinical Gastroenterology
Miriam Ben Harosh-KatzDeborah Elstein

Abstract

The purpose of this study is to ascertain the incidence of gallstones among adult patients with type 1 Gaucher disease and whether the presence of the UDPGT1 polymorphism (Gilbert syndrome), increases the incidence of gallstones. Cholelithiasis was been observed among patients with type I Gaucher disease with variable frequency. Too, studies have addressed the possibility of an association between Gilbert syndrome and formation of bilirubinate gallstones in hereditary spherocytosis wherein, like Gaucher disease, there is hemolysis of blood cell membranes. Medical records of all adult patients with type 1 disease in a referral clinic were reviewed for evidence of gallstones or cholecystectomy. Blood samples were collected for molecular analysis for Gilbert syndrome. Of 323 adult patients, 82 patients (25.4%), 54 women (65.9%) and 28 men (34.1%), had evidence of gallbladder disease (P < 0.001 relative to normal white controls). There was a statistically significant increase (P < 0.001) for all groups above the ages of 20 years other than for men aged 40 to 49 years. There was a statistically significant association between splenectomy and both cholelithiasis (P = 0.022) and Gilbert syndrome (P = 0.002). This study highlights an i...Continue Reading

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Citations

Jul 9, 2008·World Journal of Gastroenterology : WJG·Ozgur Harmanci, Yusuf Bayraktar
Mar 9, 2010·European Journal of Internal Medicine·Paula Grigorescu-SidoSimona Bucerzan
Sep 14, 2007·Clinical Genetics·M RajaE Sidransky
Mar 13, 2014·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Makoto MigitaAtsuyuki Yamataka
Jun 15, 2011·Blood·Ari Zimran
Oct 7, 2010·The Korean Journal of Hepatology·Hee Jung LeeYoung Jae Eu
Mar 10, 2018·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Michael R FreundJoseph Alberton
Nov 16, 2016·Blood Cells, Molecules & Diseases·Tomer AdarAri Zimran

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