PMID: 9435031Jan 1, 1997Paper

Increased prevalence of HIV-2 infection in hospitalized patients with severe bacterial diseases in Guinea-Bissau

Scandinavian Journal of Infectious Diseases
H NorrgrenA Nauclér

Abstract

We studied the association between HIV-2 infection and bacterial pneumonia, sepsis or pyomyositis, as well as the influence of HIV-2 infection on the clinical outcome in patients with these bacterial infections. A total of 201 consecutive hospitalized patients were included at the Simao Mendes National Hospital in Bissau, Guinea-Bissau. Age- and sex-matched controls were selected from an ongoing census in a semi-urban area of Bissau. Among 201 cases with such bacterial infection the prevalence of HIV-1 was 5.4%, HIV-2, 27.9%, and both HIV-1 and HIV-2 reactivity 6.4%. Among controls, the corresponding prevalence rates were significantly lower, 1.5%, 9.0% and 1.0%, respectively. A total of 140, 31 and 30 cases of pneumonia, sepsis and pyomyositis were included, and the differences in prevalence of HIV-2 compared with the controls also remained significant for each diagnosis separately. Lymphocyte subsets were determined in 93 consecutive patients, and the CD4 cell counts and CD4/CD8 lymphocyte ratios were markedly suppressed in the HIV-2-seropositive group. Due to excess mortality in the seropositive groups with sepsis (75.0%) and pyomyositis (25.0%), the mortality during hospitalization was significantly higher among HIV-2 infec...Continue Reading

References

Jan 1, 1992·Scandinavian Journal of Infectious Diseases·A NauclérG Biberfeld
Sep 23, 1992·JAMA : the Journal of the American Medical Association·K M De CockS B Lucas
Feb 15, 1992·Annals of Internal Medicine·C P LindanS Hulley
Sep 1, 1990·Southern Medical Journal·H M Blumberg, D S Stephens
Jan 1, 1989·Paediatric and Perinatal Epidemiology·T BjerkedalD W Hosmer
Sep 1, 1986·Scandinavian Journal of Immunology·H NielsenV Faber
Aug 1, 1995·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·H NorrgrenG Biberfeld
Feb 4, 1993·The New England Journal of Medicine·G PantaleoA S Fauci
Jun 1, 1996·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·A NauclérG Källenius

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Citations

Aug 2, 2000·Journal of Virological Methods·M SchuttenH G Niesters
Jan 27, 2007·Critical Care Medicine·Viktor Y DombrovskiyHarold L Paz
Jun 1, 2010·The Lancet Infectious Diseases·Elizabeth A ReddyJohn A Crump
May 31, 2014·PLoS Neglected Tropical Diseases·Pearl M SweKatja Fischer
Mar 1, 2012·Indian Journal of Medical Microbiology·R KannangaiG Sridharan
Aug 19, 2021·Tropical Medicine & International Health : TM & IH·Chamnab NgorCharles F Gilks

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