Increased prevalence of polycystic ovary syndrome in premenopausal women with nonalcoholic fatty liver disease

European Journal of Endocrinology
Evangeline VassilatouG Dimitriadis

Abstract

Limited data exist concerning the presence of polycystic ovary syndrome (PCOS) in premenopausal women with nonalcoholic fatty liver disease (NAFLD). We aimed to investigate the prevalence of PCOS in overweight and obese premenopausal women with NAFLD. Prospective, observational, and cross-sectional study. We studied 110 apparently healthy, overweight, and obese (BMI: 25.1-49.1 kg/m(2)) premenopausal women (age: 18-45 years) reporting no or minimal alcohol consumption for NAFLD with abdominal ultrasonography after excluding causes of secondary liver disease and for PCOS (Rotterdam criteria) with clinical examination, biochemical evaluation, and pelvic ultrasonography. Insulin resistance (IR) was assessed by homeostasis model assessment of IR (HOMA-IR), and free androgen index was calculated. NAFLD was detected in 71/110 women (64.5%). Women with NAFLD compared to women without NAFLD were more commonly diagnosed with PCOS (43.7% vs 23.1%, respectively, P=0.04), metabolic syndrome (30.2% vs 5.3%, respectively, P=0.003), and abnormal lipid profile (81.1% vs 51.3%, P=0.002). All women with abnormal glucose metabolism had NAFLD (P=0.01). Although PCOS was associated with NAFLD (OR 2.6, 95% CI: 1.1-6.2, P=0.04), in a multivariate anal...Continue Reading

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Citations

Apr 25, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Mei-Jou Chen, Hong-Nerng Ho
Jun 1, 2017·The Nurse Practitioner·Jessica Wisocky, Sonali Paul
May 31, 2018·Endocrine Connections·Katica Bajuk Studen, Marija Pfeifer
Sep 21, 2019·Endocrine·Stavroula A PaschouAndromachi Vryonidou
Jan 20, 2021·Diabetes, Obesity & Metabolism·Bertrand CariouArun J Sanyal
Sep 8, 2021·The Journal of Clinical Endocrinology and Metabolism·Claire FalzaranoStanley Andrisse

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