Increased production of CXCL16 in experimental and clinical heart failure: a possible role in extracellular matrix remodeling

Circulation. Heart Failure
Christen Peder DahlGeir Christensen

Abstract

Inflammation has been implicated in the pathogenesis of heart failure (HF), but knowledge about the production and role of inflammatory actors remains incomplete. On the basis of its role in vascular inflammation, vascular proliferation, and matrix degradation, we hypothesized a role for the chemokine CXCL16 in the pathogenesis of myocardial remodeling and development of HF. Our main findings were (1) patients with chronic HF (n=188) had increased plasma levels of CXCL16, which correlated with disease severity. (2) Left ventricular tissue from patients with end-stage HF (n=8) showed enhanced CXCL16 levels compared with nonfailing left ventricular (n=6) as assessed by Western blotting. (3) In mice with postmyocardial infarction HF, expression of CXCL16, as assessed by real-time RT-PCR, was increased in the infarcted and the noninfarcted areas of left ventricular 3 and 7 days after coronary ligation, indicating early onset of CXCL16 production. Furthermore, mice exposed to aortic banding had enhanced CXCL16 expression in left ventricular, indicating that CXCL16 expression is not related to ischemia alone. (4) In vitro, CXCL16 promoted proliferation and impaired collagen synthesis in myocardial fibroblasts, and in cardiomyocytes a...Continue Reading

References

Mar 11, 1999·The American Journal of Cardiology·P AukrustL Gullestad
Aug 3, 1999·The Journal of Clinical Investigation·S FrantzR A Kelly
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·L J De WindtJ D Molkentin
Apr 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A WilbanksM Briskin
Mar 23, 2002·Circulation Research·Francis G Spinale
May 16, 2003·The New England Journal of Medicine·Mariell Jessup, Susan Brozena
Dec 31, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Ryoko YamauchiToru Kita
Jan 24, 2004·Acta Physiologica Scandinavica·G FlorholmenG Christensen
Feb 28, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Dirk M WuttgeAllan Sirsjö
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Soeren AbelAndreas Ludwig
Jul 8, 2005·European Journal of Haematology·Per O IversenGeir Christensen
Oct 4, 2005·Arthritis and Rheumatism·Toshihiro NankiNobuyuki Miyasaka
Aug 24, 2006·Journal of Molecular and Cellular Cardiology·G FlorholmenA Yndestad
Jan 30, 2007·Journal of the American College of Cardiology·Michael LehrkeMuredach P Reilly
May 5, 2007·Thrombosis and Haemostasis·Andreas Ludwig, Christian Weber
Jul 31, 2007·Rheumatology International·Yasunori KageyamaAkira Nagano
Mar 21, 2008·European Journal of Heart Failure·Christen Peder DahlArne Yndestad

❮ Previous
Next ❯

Citations

Feb 7, 2014·Cardiovascular Research·Alessandra GhigoEmilio Hirsch
May 28, 2014·Cytokine & Growth Factor Reviews·María Concepción IzquierdoAlberto Ortiz
Jul 11, 2012·Basic Research in Cardiology·Arkady RutkovskiyJarle Vaage
Sep 17, 2014·International Journal of Cardiology·Oliver BorstChristine S Zuern
Sep 20, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yanhui WangDe-an Guo
Aug 21, 2015·Journal of Atherosclerosis and Thrombosis·Ivan JovanovićAleksandra Stanković
Mar 1, 2012·Acta Veterinaria Hungarica·Magdalena LójMichał Jank
May 30, 2013·International Journal of Cardiology·Christen Peder DahlThor Ueland
May 28, 2014·Cellular Immunology·Shuang ZhangEdward B Thorp
Apr 18, 2008·Experimental and Molecular Pathology·Wei LiuManling Ma
Jun 21, 2017·American Journal of Nephrology·Wenjin LiuJunwei Yang
Jun 16, 2012·Cardiology·Lars GullestadPål Aukrust
Feb 24, 2015·World Journal of Experimental Medicine·Valter Lubrano, Silvana Balzan
Aug 31, 2013·Circulation Research·Francis G Spinale, Michael R Zile
Oct 2, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Anna M JanssonKenneth Caidahl
Jun 13, 2012·International Heart Journal·Sebastian SzmitGrzegorz Opolski
Sep 27, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Thomas AndersenFrederic Kontny
Jun 14, 2019·Frontiers in Immunology·Fareed AhmadKnut Schäkel
Dec 29, 2020·Pharmacology & Therapeutics·Tomasz P MikolajczykTomasz J Guzik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.