Increased production of inflammatory cytokines in cultured CD4+ cells from patients with HTLV-I-associated myelopathy

The Tohoku Journal of Experimental Medicine
Y NishiuraS Nagataki

Abstract

We investigated the production of inflammatory cytokines derived from cultured T cells of peripheral blood lymphocytes (PBL) in 14 patients with HTLV-I-associated myelopathy (HAM). The production of inflammatory cytokines, such as tumor necrosis factor-alpha, interferon-gamma, and granulocyte-macrophage colony stimulating factor, was significantly increased in patients with HAM, compared to HTLV-I seronegative controls. On the contrary, interleukin-4 production in cultured T cells was detected in only two patients with HAM, and not detected in HTLV-I seronegative controls. These results suggest that the production of inflammatory cytokines derived from TH1 cell population was simultaneously exaggerated in HAM patients. Interestingly, accelerated production of these cytokines was derived from CD4+ cells, which are main target cells in HTLV-I infection. These findings suggest that an inflammatory state in the central nervous system might be related to the pathogenesis of HAM.

References

Aug 15, 1991·The New England Journal of Medicine·M K Sharief, R Hentges
Dec 1, 1990·Journal of Neuroimmunology·A SuzumuraT Marunouchi
Apr 1, 1988·Annals of Neurology·K W Selmaj, C S Raine
Jan 1, 1987·Annual Review of Immunology·W E Paul, J Ohara
Jul 1, 1993·Journal of Neuropathology and Experimental Neurology·F UmeharaM Osame
Feb 1, 1993·Journal of Neuroimmunology·Y Kuroda, M Matsui

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Citations

Dec 4, 2003·The Journal of Laboratory and Clinical Medicine·Koto NakashimaKatsumi Eguchi
May 23, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Monique R AndersonSteven Jacobson
Oct 17, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Ana Lúcia Borges StarlingOlindo Assis Martins-Filho
Feb 24, 2016·Journal of Immunology Research·Clara Mônica LimaEdgar M Carvalho
Oct 20, 2010·Blood·Clarissa Rodrigues NascimentoJuliana Echevarria-Lima
Aug 26, 2014·BMC Infectious Diseases·Raimundo CoutinhoRita Elizabeth Mascarenhas
Nov 16, 2012·Revista Da Sociedade Brasileira De Medicina Tropical·Anselmo SouzaEdgar Marcelino de Carvalho
Jul 10, 2019·Journal of Leukocyte Biology·Raquel Cavalcanti De AlbuquerqueJuliana Echevarria-Lima
Jun 26, 2004·The Journal of General Virology·Madeleine Duc DodonLouis Gazzolo
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter K C GoonCharles R M Bangham

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