Increased production of nitric oxide by neutrophils from patients with chronic granulomatous disease on interferon-gamma treatment

International Immunopharmacology
Fariba Naderi beniMostafa Moin

Abstract

Chronic granulomatous disease (CGD) is a rare immunodeficiency disorder in which phagocytic leukocytes fail to generate superoxide (O(2)(-)) and antimicrobial oxidants. The therapeutic validity of interferon-gamma (IFN-γ) has been well established in CGD patients but its underlying mechanisms remain poorly understood. One probable mechanism has been suggested to be modulation of nitric oxide (NO) release from phagocytic cells. Herein, we investigated NO production from neutrophil cells in CGD patients on treatment with IFN-γ in vivo and in vitro. We measured NO levels in sera from 19 CGD patients (group I: 7 patients treated with TMP-SMX, group II: 12 patients treated with TMP-SMX and IFN-γ simultaneously) and healthy control individuals (8 cases). We also measured NO production from neutrophils in both patients groups as well as in control group after adding 100 U IFN-γ in vitro. Our results showed that there was a significant difference between the groups in the NO levels of serum; patients who received IFN-γ had significantly higher amount of NO than the other groups. Besides, NO levels increased significantly after adding 100 U IFN-γ in vitro in three studied groups, considerably in the patients on treatment with IFN-γ. As ...Continue Reading

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Citations

Jun 19, 2013·The British Journal of Nutrition·Rosana G C SantosValbert N Cardoso
Dec 20, 2012·DNA and Cell Biology·Sae Kyung Lee, Jeak Ling Ding
Feb 15, 2013·Immunological Reviews·Jay K Kolls
Sep 11, 2016·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Lorenzo LoffredoFrancesco Violi
May 11, 2018·Journal of the Pediatric Infectious Diseases Society·Maria A Slack, Isaac P Thomsen
Jun 12, 2020·Clinical Reviews in Allergy & Immunology·Hsin-Hui YuBor-Luen Chiang
Nov 23, 2016·Clinical Reviews in Allergy & Immunology·Pandiarajan VigneshSurjit Singh
Dec 11, 2019·International Journal of Environmental Research and Public Health·María Elena SotoRicardo Gamboa
Apr 1, 2020·F1000Research·Giorgia Bucciol, Isabelle Meyts
Mar 7, 2020·Immunopharmacology and Immunotoxicology·Monireh MohsenzadeganShahnam Sedigh Maroufi

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