PMID: 11911993Mar 26, 2002Paper

Increased production of nitric oxide stimulated by interferon-gamma from peripheral blood monocytes in patients with complex regional pain syndrome

Neuroscience Letters
Craig T Hartrick

Abstract

This study examines immediate nitric oxide (NO) release from monocytes following interleukin-1beta (IL-1beta), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) challenge in patients with complex regional pain syndrome (CRPS). Study patients exhibited the following: (1), mechanical allodynia; (2), evidence of either vasomotor or sudomotor disturbance; and (3), concordant painful allodynia documented with quantitative sensory testing that was temporarily abolished with sympathetic block. Ten subjects (CRPS, N=5; control, N=5) were enrolled. Peripheral blood monocytes were challenged with 100 microl of IL-1beta (1 ng), IFN-gamma (1 ng), TNF-alpha (0.01 ng), and normal saline (NS) and the resultant immediate NO release measured. Subjects with CRPS exhibited a statistically significant increase in NO release in response to IFN-gamma (P<0.012) compared with controls. The NO responses to IFN-gamma in excess of NS (P<0.025) and as the ratio IFN-gamma/NS (P<0.022) were also significantly increased.

References

Jul 1, 1978·Journal of Neurology, Neurosurgery, and Psychiatry·L Loh, P W Nathan
Jun 1, 1996·Journal of the Neurological Sciences·Y ChoiJ R Tobin
Mar 12, 1998·Anesthesia and Analgesia·C T HartrickJ S Patterson
Dec 23, 1998·Archives of Physical Medicine and Rehabilitation·G M RibbersM de Metz

❮ Previous
Next ❯

Citations

Apr 3, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Rame Taha, Gilbert Blaise
Nov 3, 2006·Inflammation·Edward C T H TanR Jan A Goris
Jan 15, 2003·Current Pain and Headache Reports·Eric Chevlen
Sep 10, 2008·Current Pain and Headache Reports·Michael L Oshinsky
Nov 19, 2003·Nitric Oxide : Biology and Chemistry·A PanossianG Wikman
Jan 9, 2008·The Clinical Journal of Pain·George GroenewegFreek J Zijlstra
Sep 24, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Cielito C Reyes-GibbySanjay Shete
Jun 28, 2007·Expert Opinion on Investigational Drugs·Annemarie LedeboerKirk W Johnson
Sep 7, 2007·Annals of the New York Academy of Sciences·F BlaesF Birklein
Jun 1, 2006·Expert Review of Neurotherapeutics·Robert J SchwartzmanJohn Grothusen
Aug 9, 2016·Scientific Reports·Marguerite K McDonaldSeena K Ajit
Dec 15, 2006·Pain Practice : the Official Journal of World Institute of Pain·Craig T Hartrick
Nov 6, 2018·Pain Management·Christian MaihöfnerKai-Uwe Kern
Feb 14, 2009·Pain Practice : the Official Journal of World Institute of Pain·Marissa de MosFrank J P M Huygen
Jun 21, 2005·Pain·Guillermo M AlexanderRobert J Schwartzman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.