Increased proinflammatory cytokine production in adipose tissue of obese patients with chronic kidney disease.

Wiener klinische Wochenschrift
Vladimír TeplanVladimir Teplan

Abstract

Obesity is a known high-risk factor for the development of vascular diseases and chronic kidney disease (CKD). In this study we aimed to elucidate the impact of adipose tissue on the inflammatory state in CDK patients with obesity. A cohort of 40 patients with CKD (stages 3-4) with mild proteinuria (2.3-3.5 g/day) were analyzed in a prospective cross-sectional study: single blood samples and visceral and subcutaneous samples of adipose tissue were taken from 20 patients with obesity and 20 without obesity (control group) during elective abdominal surgery (laparoscopic cholecystectomy). Serum concentrations of asymmetric dimethylarginine (ADMA), adiponectin, C-reactive protein, interleukin-6, tumor necrosis factor-alpha, pentosidine and monocyte chemoattractant protein-1 were measured. Messenger RNA expression of tumor necrosis factor-alpha, monocyte chemoattractant protein-1, adiponectin receptors 1 and 2, and immunocompetent cell marker CD68 was measured in subcutaneous and visceral fat samples using real-time PCR. Adipose tissue was examined immunohistochemically for CD68-positive cells. Other biochemical parameters (insulin, glycated hemoglobin, cholesterol, LDL cholesterol, and triglycerides) were assessed in the two groups...Continue Reading

References

May 1, 1995·The Journal of Clinical Investigation·G S HotamisligilB M Spiegelman
Mar 27, 1999·Biochemical and Biophysical Research Communications·Y AritaY Matsuzawa
Apr 12, 2000·Circulation·R H BögerJ P Cooke
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·K HottaY Matsuzawa
Feb 24, 2001·Nature·C M SteppanM A Lazar
Aug 15, 2001·The Journal of Clinical Endocrinology and Metabolism·W S YangL M Chuang
Feb 22, 2002·The New England Journal of Medicine·Elif Arioglu OralAbhimanyu Garg
May 8, 2002·The Journal of Clinical Endocrinology and Metabolism·Philip G McTernanSudhesh Kumar
May 22, 2002·The Journal of Clinical Investigation·Kitt Falk PetersenGerald I Shulman
May 29, 2002·The Journal of Biological Chemistry·Naoto KubotaTetsuo Noda
Oct 29, 2003·Circulation·Tomasz MazurekYi Shi
Dec 11, 2003·Atherosclerosis. Supplements·Rainer H Böger, Carmine Zoccali
Jul 29, 2004·Metabolism: Clinical and Experimental·Hannu PäiväReijo Laaksonen
Dec 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Katarzyna KrzyzanowskaGuntram Schernthaner
Dec 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Jitka HousovaMartin Haluzik
Mar 4, 2005·Journal of the American Society of Nephrology : JASN·Bjoern BeckerUNKNOWN MMKD Study Group
Mar 15, 2005·Scandinavian Journal of Urology and Nephrology·Qiang YaoPeter Stenvinkel
Mar 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Edward D JavorPhillip Gorden
May 3, 2005·The Journal of Clinical Investigation·Kathryn E Wellen, Gökhan S Hotamisligil
Aug 18, 2005·Clinical Science·Christine M KusminskiSudhesh Kumar
Jan 6, 2006·The Journal of Clinical Investigation·Jaap G Neels, Jerrold M Olefsky
Mar 2, 2006·The Journal of Clinical Endocrinology and Metabolism·Tracey McLaughlinPhilip S Tsao
Apr 13, 2006·Current Opinion in Nephrology and Hypertension·Carmine Zoccali, Jan T Kielstein
Aug 26, 2006·Archives of Physiology and Biochemistry·Phillip Gorden, Jean Y Park
Sep 29, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yvonne Y ShenPhilip W Peake
Mar 5, 2008·Mayo Clinic Proceedings·Paresh Dandona
Jun 21, 2008·Journal of the American College of Cardiology·Charles R Harper, Terry A Jacobson

❮ Previous
Next ❯

Citations

Feb 22, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Megan M Lo, Mark Mitsnefes
Jul 31, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·M A KamimuraL Cuppari
Mar 19, 2013·Annals of Vascular Surgery·Christine R MauroC Keith Ozaki
Oct 13, 2012·The Journal of Surgical Research·Karen J HoCharles Keith Ozaki
Dec 28, 2011·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Vladimír TeplanMilena Stollová
Dec 10, 2015·Lipids in Health and Disease·Masato OhsawaSatoshi Umemura
May 7, 2016·World Journal of Nephrology·Juan TuRobert H Mak
Mar 14, 2014·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Vladimir Teplan JrRobert Gurlich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.