PMID: 9654195Jul 8, 1998Paper

Increased prosomal proteins in breast cancer cells and in neighboring normal cells in Parsi and non-Parsi populations

Journal of Cancer Research and Clinical Oncology
A Bhui-KaurJ P Bureau

Abstract

Monoclonal antibodies were raised against the prosomal proteins p27K, p29K and the prosome-like protein p21K (PLP) from normal breast glandular cells and from benign and malignant tumors. They were used to clarify the involvement of prosomes in tumorigenesis of human breast cells. Immunostaining showed the distribution of prosomes in the cytoplasm and nuclei of cells from European normal women (EN) and Parsi (P) and non-Parsi (NP) benign (B) and malignant (M) tissues. The flow-cytometry studies showed an increased mean percentage of labeled cells, particularly with anti-p27K prosomal protein mAb, in malignant tissue from NP compared to EN. The p21K data indicated an increase in the number of cells labeled by flow-cytometry studies in all groups compared to EN, while p29K-expressing cells were more abundant in NPN, PB, PM and NPM. Intergroup comparison showed that the mean percentage of cells labeled with anti-p27K and anti-p29K was significantly higher in PB than in NPB, as seen by flow cytometry, whereas there was a higher production or accumulation of the p21K (PLP) prosomal protein in NPM than in PM, as seen by immunostaining. By comparison with EN, there were also significantly more normal cells containing the three antigen...Continue Reading

Citations

Jan 17, 2002·Journal of Immunological Methods·Dominique DutaudAhmed Ouali
Jul 19, 2012·In Vitro Cellular & Developmental Biology. Animal·Jian-Guo HuangXin Jin
Nov 12, 2013·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Hosni M SalamaTarneem Darwish
Apr 9, 2010·European Journal of Haematology·Jan SterzIvana von Metzler
Jul 8, 2008·Biochimica Et Biophysica Acta·Stephan U Sixt, Burkhardt Dahlmann

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