Increased pulmonary vascular resistance in early stage systemic hypertension: a resting and exercise stress echocardiography study

The Canadian Journal of Cardiology
Olga VrizEduardo Bossone

Abstract

In early stage uncomplicated systemic hypertension (HT), increased pulmonary vascular resistance (PVR) has been reported at rest, but more rarely during exercise. Recently, limits of normal for stress echocardiography in the evaluation of the pulmonary circulation have been better defined. We therefore used this approach to assess the pulmonary circulation in early HT. One hundred thirteen patients with mild to moderate untreated, uncomplicated HT (blood pressure, 152 ± 19/89 ± 11 mm Hg, heart rate, 70 ± 13 beats per minute) and 345 age- and sex-matched healthy control subjects underwent resting Doppler echocardiography with estimation of mean pulmonary arterial pressure (mPAP), left atrial pressure (LAP), and cardiac output (CO). Measurements were repeated at exercise stress test in 25 patients from each group. At rest, hypertensive patients had normal right and left ventricular structure and function, higher systemic vascular resistance, mPAP (16 ± 5 vs 14 ± 5 mm Hg; P < 0.0001), and PVR (1.3 ± 1.1 vs 1.0 ± 1.2 Wood units; P = 0.006) than control participants, but similar LAP. During exercise, hypertensive patients showed a lower maximum workload and CO and higher peak mPAP than control subjects, but a similar increase in LAP...Continue Reading

References

Jun 1, 1978·Circulation·M T OlivariM D Guazzi
Jun 1, 1992·Journal of the American College of Cardiology·A GanauJ H Laragh
Feb 1, 1989·Circulation·M D GuazziG Tamborini
Nov 1, 1988·Journal of Hypertension·R FagardA Amery
May 1, 1988·The American Journal of Cardiology·R FagardA Amery
Mar 18, 2000·Hypertension·S JuliusP Palatini
Apr 6, 2002·Circulation Research·Peter QuehenbergerOswald Wagner
Feb 8, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·John T ReevesKurt R Stenmark
May 9, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Deepak R TalrejaJae K Oh
Jun 15, 2007·The Journal of Membrane Biology·Graziello GeneauLaurent Cronier
Jan 24, 2009·American Journal of Respiratory and Critical Care Medicine·Micah R FisherPaul M Hassoun
Jun 12, 2009·Journal of Hypertension·Cesare CuspidiGiuseppe Mancia
Aug 18, 2010·Hypertension·Anoop Shankar, Jie Xiao
Jun 2, 2011·Heart·Giancarlo TodiereRoberto Pedrinelli
Jun 28, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Olga VrizFrancesco Antonini-Canterin
Mar 1, 2012·The European Respiratory Journal·Alice HuertasMarc Humbert
Jun 27, 2012·The Journal of Physiology·Sophie LalandeRobert Naeije
Aug 22, 2012·Circulation·Marco Guazzi, Barry A Borlaug
Nov 13, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Eduardo BossoneRobert Naeije
Sep 26, 2013·Circulation·Gregory D LewisMelvyn Rubenfire
Feb 7, 2014·Respiratory Research·Samantha GomartLaurence Dewachter

❮ Previous
Next ❯

Citations

Apr 4, 2015·The Canadian Journal of Cardiology·Eduardo BossoneMelvyn Rubenfire
Oct 1, 2019·Journal of Hypertension·Olga VrizRobert Naeije
May 8, 2020·European Heart Journal Cardiovascular Imaging·Kevin FortonRobert Naeije
Oct 9, 2015·Current Opinion in Cardiology·Eduardo BossoneEkkehard Grünig

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.