Increased QT dispersion in breath-holding spells

Acta Paediatrica
F J DiMario

Abstract

Breath-holding spells (BHS) in children can be a frightening and clinically challenging paroxysmal, non-epileptic childhood disorder. The pathophysiology has been found to incorporate central nervous system dysregulation in addition to an underlying genetic predisposition. Akalin and colleagues found group differences (BHS versus controls) in QT dispersion and QTc dispersion. These differences, however, may have been affected mainly by normal sinus arrhythmia from the predominant cyanotic BHS cohort. The subtle differences measured in the current study between pallid and cyanotic breath-holder groups, in terms of increased QTc dispersion in the pallid group, may represent an additional factor impacted upon by the resting state of underlying central autonomic dysregulation.

References

Aug 10, 1995·The New England Journal of Medicine·W H Franklin, R W Hickey
Jul 1, 1993·Pediatric Neurology·F J DiMario, J A Burleson
Jun 1, 1997·Journal of the American College of Cardiology·D J PinskyJ S Steinberg
Nov 14, 1997·The American Journal of Cardiology·J KautznerM Malik
Feb 18, 2003·European Journal of Clinical Investigation·S LeeS R Heller
Jul 13, 2004·Acta Paediatrica·F AkalinY Yilmaz

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Citations

Aug 23, 2011·The American Orthoptic Journal·Marianne Piano, Anna R O'Connor

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