Increased quinolinate immunoreactivity in the peripheral blood monocytes/macrophages from SIV-infected monkeys

Journal of Neurovirology
A M NamboodiriC J Gibbs

Abstract

Quinolinate (QUIN), a metabolite in the kynurenine pathway of tryptophan degradation and a neurotoxin that is thought to act through the NMDA receptor system, was localized in cultured peripheral blood monocytes/macrophages from SIV-infected monkeys using a recently developed immunohistochemical method. Significant increases in QUIN immunoreactive (IR) cells were detected in all five SIV-infected monkeys examined. Multinucleated giant cells, a hallmark of lentiviral infection, were visible in selected samples. Treatment with the QUIN precursors, tryptophan and kynurenine, increased the number of QUIN-IR cells in both the control and SIV-infected preparations, perhaps by a mass action mechanism. We hypothesize that in SIV-infected monkeys, infiltrating monocytes/macrophages contribute to the high level of brain QUIN and associated neuropathology.

Citations

Aug 11, 2000·Toxicon : Official Journal of the International Society on Toxinology·T W Stone
Oct 3, 2003·The Lancet Infectious Diseases·Michael F Murray
Jul 10, 2003·Immunology and Cell Biology·John R Moffett, Ma Aryan Namboodiri
Aug 28, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Trevor W StoneL Gail Darlington
Mar 15, 2018·The Clinical Journal of Pain·Marc SorelJean-Pascal Lefaucheur
Oct 31, 2002·Nature Reviews. Drug Discovery·Trevor W Stone, L Gail Darlington
Jul 1, 2016·Clinical Science·Abdulla A-B BadawyJohn R Moffett
Jul 10, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M P HeyesS P Markey
Aug 23, 2007·Metabolic Brain Disease·T W StoneL G Darlington

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