Increased R2* in the Caudate Nucleus of Asymptomatic Welders

Toxicological Sciences : an Official Journal of the Society of Toxicology
Eun-Young LeeXuemei Huang

Abstract

Welding has been associated with neurobehavioral disorders. Welding fumes contain several metals including copper (Cu), manganese (Mn), and iron (Fe) that may interact to influence welding-related neurotoxicity. Although welding-related airborne Fe levels are about 10-fold higher than Mn, previous studies have focused on Mn and its accumulation in the basal ganglia. This study examined differences in the apparent transverse relaxation rates [R2* (1/T2*), estimate of Fe accumulation] in the basal ganglia (caudate nucleus, putamen, and globus pallidus) between welders and controls, and the dose-response relationship between estimated Fe exposure and R2* values. Occupational questionnaires estimated recent and lifetime Fe exposure, and blood Fe levels and brain magnetic resonance imaging (MRI) were obtained. Complete exposure and MRI R2* and R1 (1/T1: measure to estimate Mn accumulation) data from 42 subjects with welding exposure and 29 controls were analyzed. Welders had significantly greater exposure metrics and higher whole-blood Fe levels compared with controls. R2* in the caudate nucleus was significantly higher in welders after controlling for age, body mass index, respirator use, caudate R1, and blood metals of Cu and Mn, ...Continue Reading

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Citations

Jul 29, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Eun-Young LeeXuemei Huang
Jan 11, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Eun-Young LeeXuemei Huang
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Mar 11, 2021·Parkinsonism & Related Disorders·Eun-Young LeeXuemei Huang

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