Increased radial diffusivity in spinal cord lesions in neuromyelitis optica compared with multiple sclerosis.

Multiple Sclerosis : Clinical and Laboratory Research
Eric C KlawiterAnne H Cross

Abstract

Multiple sclerosis (MS) and neuromyelitis optica (NMO) both affect spinal cord with notable differences in pathology. Determine the utility of diffusion tensor imaging (DTI) to differentiate the spinal cord lesions of NMO from MS within and outside T2 lesions. Subjects greater than or equal to 12 months from a clinical episode of transverse myelitis underwent a novel transaxial cervical spinal cord DTI sequence. Ten subjects with NMO, 10 with MS and 10 healthy controls were included. Within T2 affected white matter regions, radial diffusivity was increased in both NMO and MS compared with healthy controls (p<0.001, respectively), and to a greater extent in NMO than MS (p<0.001). Axial diffusivity was decreased in T2 lesions in both NMO and MS compared with controls (p<0.001, p=0.001), but did not differ between the two diseases. Radial diffusivity and fractional anisotropy within white matter regions upstream and downstream of T2 lesions were different from controls in each disease. Higher radial diffusivity within spinal cord white matter tracts derived from diffusion tensor imaging were appreciated in NMO compared with MS, consistent with the known greater tissue destruction seen in NMO. DTI also detected tissue alterations o...Continue Reading

References

Jan 1, 1994·Biophysical Journal·P J BasserD LeBihan
Aug 1, 1993·Annals of Neurology·R N MandlerM Kornfeld
Jun 1, 1996·Journal of Magnetic Resonance. Series B·P J Basser, C Pierpaoli
Sep 25, 1999·Neurology·D M WingerchukB G Weinshenker
Oct 18, 2001·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·I V AllenG Nevin
Jun 22, 2002·Brain : a Journal of Neurology·Claudia F LucchinettiHans Lassmann
Feb 25, 2005·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·M Filippi, M A Rocca
Apr 27, 2005·NeuroImage·Christopher D KroenkeJeffrey J Neil
May 3, 2005·NeuroImage·Sheng-Kwei SongRegina C Armstrong
Jul 20, 2005·Nuclear Medicine and Biology·Douglas J RowlandAbraham Z Snyder
Dec 13, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Christopher D KroenkeJeffrey J Neil
May 24, 2006·Neurology·D M WingerchukB G Weinshenker
Feb 7, 2007·Brain : a Journal of Neurology·Shanu F RoemerClaudia F Lucchinetti
Mar 14, 2007·Neurology·I MiyazawaY Itoyama
Jul 27, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Joong Hee KimSheng-Kwei Song
Aug 30, 2008·NMR in Biomedicine·Junqian XuSheng-Kwei Song
Feb 19, 2009·Journal of Neuroradiology. Journal De Neuroradiologie·C CassinottoP Cabre
Mar 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew D BuddeSheng-Kwei Song
May 6, 2009·European Radiology·Wolfgang KramplaWolfgang Kristoferitsch
Jun 24, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·B BenedettiM Filippi
Jun 27, 2009·Journal of Magnetic Resonance Imaging : JMRI·Wim van HeckePaul M Parizel
Aug 6, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Patrick FreundOlga Ciccarelli
Jan 18, 2011·NeuroImage·Eric C KlawiterTammie L Benzinger

❮ Previous
Next ❯

Citations

Apr 25, 2013·Translational Psychiatry·J LagopoulosI B Hickie
Jun 15, 2013·AJNR. American Journal of Neuroradiology·Y BarnettM H Barnett
Mar 29, 2014·Clinical and Experimental Immunology·S JariusF Paul
Apr 23, 2014·Journal of Magnetic Resonance Imaging : JMRI·Christine GohPramit M Phal
Sep 25, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Maciej JuryńczykJacqueline Palace
Nov 28, 2012·NeuroImage·Junqian XuSheng-Kwei Song
Dec 24, 2013·Sleep Medicine·Christian Veauthier, Friedemann Paul
Aug 5, 2016·NeuroImage. Clinical·Alexander KlistornerStuart L Graham
May 16, 2014·Multiple Sclerosis : Clinical and Laboratory Research·George TackleyJacqueline Palace
Feb 1, 2018·Journal of Neurology·Diane F van RappardPetra J W Pouwels
Mar 8, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Mickael BonnanPhilippe Cabre
Aug 7, 2013·Continuum : Lifelong Learning in Neurology·Eric C Klawiter
Mar 4, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Teodoro Martín NoguerolAntonio Luna
May 3, 2020·Expert Review of Neurotherapeutics·Maria A RoccaMassimo Filippi
Oct 6, 2016·Experimental and Therapeutic Medicine·Jiafeng ChenShaokuan Fang
Dec 22, 2017·Human Brain Mapping·Daniel C M O'DohertyJim Lagopoulos
Nov 19, 2020·Brain : a Journal of Neurology·Romina MarianoJacqueline A Palace
Oct 9, 2018·NeuroImage·Daniel E GustavsonWilliam S Kremen

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
dissection

Software Mentioned

fslview
Statistical Package for the Social Sciences

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Eun-Kee JeongDennis L Parker
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Emine Ulku SaritasDwight G Nishimura
© 2022 Meta ULC. All rights reserved