Increased rate of factor V Leiden mutation in patients with cerebral venous thrombosis

Journal of Neurology
M WeihK M Einhäupl

Abstract

We investigated the association between cerebral venous thrombosis and hereditary resistance to activated protein C (APC) in 12 consecutive German patients with non-fatal cerebral venous thrombosis and in 187 controls without a history of thrombotic disorder. Three patients (25%) had a mutation in the factor V Leiden gene against only one subject in the control group. This difference was significant (P < 0.05), with an odds ratio of 11.7 (1.5-87; 95% confidence interval). Two patients carrying the mutation had additional common risk factors for thrombosis, and 2 had a positive family history of thromboembolism. We conclude that inherited APC resistance by a mutation in factor V Leiden is an important risk factor in non-fatal cerebral venous thrombosis. We recommend testing for APC resistance and, if abnormal for factor V Leiden mutation in patients with cerebral venous thrombosis.

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Citations

Aug 20, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Pietro SpennatoGiuseppe Cinalli
Jun 17, 1999·Journal of the Neurological Sciences·S ChaturvediJ Dzieczkowski
Jul 15, 2006·Journal of the Neurological Sciences·Nagaraja DindagurRita Christopher
Nov 26, 2015·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Mohammad SaadatniaEhsan Kheradmand
Oct 24, 2001·Journal of Child Neurology·J K LynchJ K Grether
Sep 29, 2001·Journal of Child Neurology·S BuoniA Fois
Jan 12, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·N DayanV Tagalakis
Jul 12, 2002·American Journal of Hematology·Thomas BombeliJoerg Fehr
Feb 5, 2011·Stroke; a Journal of Cerebral Circulation·Gustavo SaposnikUNKNOWN American Heart Association Stroke Council and the Council on Epidemiology and Prevention
Dec 4, 1998·Stroke; a Journal of Cerebral Circulation·P LüdemannE B Ringelstein
Oct 21, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·I MitsievB Hocher
Jan 13, 2018·Translational Stroke Research·Jayantee KalitaRajesh K Singh
Mar 19, 2004·Neurosurgery·Devin K BinderMichael W McDermott

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