PMID: 8991854Aug 1, 1996Paper

Increased rates of duodenal mucosal protein synthesis in vivo in patients with untreated coelia disease

Gut
I M NakshabendiM J Rennie

Abstract

A robust, reproducible method for the measurement of protein synthesis in the gastrointestinal mucosa was applied to investigate possible differences between the rate of duodenal mucosal protein synthesis in coeliac patients and normal control subjects. Eight patients, means (SD) (51 (10) years, 57 (11) kg, 160 (6) cm) with newly diagnosed untreated coeliac disease and seven control subjects (48 (11) years, 71.5 (12) kg, 172 (10) cm) received primed, continuous, intragastric (IG) and intravenous (i.v.) infusions of L-[1-13C]leucine and L-[1-13C]valine after an overnight fast. Distal duodenal biopsy specimens were obtained at endoscopy performed after 240 minutes of infusion. Protein synthesis was calculated from protein labelling relative to intracellular free amino acid enrichment, after appropriate mass spectrometric measurements. Rates of duodenal protein synthesis were significantly greater in coeliac patients than in control subjects (i.v. tracer, coeliac v control, 3.58 (0.45) v 2.26 (0.22)%/h, p< 0.05; IG tracer, 6.25 (0.97) v 2.34 (0.52)%/h respectively, p < 0.01). The rates of mucosal protein synthesis calculated on the basis of the tracer infused via the intragastric route were higher in patients with coeliac disease ...Continue Reading

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Citations

May 31, 2012·Amino Acids·Julien BertrandMoïse Coëffier
May 20, 1998·Baillière's Clinical Endocrinology and Metabolism·P B SoetersN E Deutz
Aug 6, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Christelle GuilletStéphane Walrand
Apr 5, 2007·Digestive Diseases and Sciences·Sophie ClaeyssensMoïse Coëffier
Jan 23, 1998·Scandinavian Journal of Gastroenterology·E CapristoG Gasbarrini
Jan 29, 2000·Gastroenterology·M CharltonK S Nair
Apr 25, 2007·Scandinavian Journal of Gastroenterology·J Arturo Garcia-HorsmanPekka T Männistö
Dec 10, 2009·The American Journal of Gastroenterology·Moïse CoëffierPhilippe Ducrotté
Mar 23, 1999·Nature·J E Frey
Mar 29, 2002·European Journal of Immunology·Michelle S TengJohn Trowsdale
Apr 22, 2011·The American Journal of Clinical Nutrition·Moïse CoëffierPierre Déchelotte
May 14, 2014·Neurologia i neurochirurgia polska·Aldona Warsz-WianeckaZofia Kazibutowska
Jul 5, 2002·The Journal of Nutrition·Sabine MercierPhilippe Patureau Mirand
Apr 8, 1998·The American Journal of Physiology·C Bouteloup-DemangeB Beaufrère
Dec 22, 1999·The American Journal of Physiology·I M NakshabendiM J Rennie
May 9, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·C Bouteloup-DemangeP Dechelotte
Apr 6, 2000·American Journal of Physiology. Endocrinology and Metabolism·P RittlerW H Hartl
Mar 1, 2005·The Journal of Nutrition·Magali FaureOlivier Ballèvre
Apr 19, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Moïse CoëffierPierre Déchelotte

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