Increased regulatory T cells in acute lymphoblastic leukaemia patients

Hematology
Siti-Zuleha IdrisMaha Abdullah

Abstract

Regulation in adaptive immune response balances a fine line that prevents instigation of self-damage or fall into unresponsiveness permitting abnormal cell growth. Mechanisms that keep this balance in check include regulatory T cells (Tregs). Tregs consist of a small but heterogeneous population, which may be identified by the phenotype, CD3+CD4+CD25+CD127-. The role of Tregs in pathogenesis of cancers is thus far supported by evidence of increased Tregs in various cancers and may contribute to poorer prognosis. Tregs may also be important in acute leukaemias. A review of the literature on Tregs in acute leukaemias was conducted and Tregs were determined in B-cell acute lymphoblastic leukaemias (ALLs). Studies on Tregs in B-cell ALL are few and controversial. We observed a significantly increased percentage of Tregs (mean±SD, 9.72 ± 3.79% vs. 7.05 ± 1.74%; P = 0.047) in the bone marrow/peripheral blood of ALL (n = 17) compared to peripheral blood of normal controls (n = 35). A positive trend between Tregs and age (R = 0.474, P = 0.055, n = 17) implicates this factor of poor prognosis in B-cell ALL. Tregs in cancer are particularly significant in immunotherapy. The manipulation of the immune system to treat cancer has for a long...Continue Reading

References

Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M SmithR Ungerleider
Jan 11, 1997·Lancet·N H Russell
Mar 23, 2002·Nature Reviews. Immunology·Lucy S K Walker, Abul K Abbas
Sep 2, 2004·Nature Medicine·Steven A RosenbergNicholas P Restifo
Mar 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Estelle BettelliMohamed Oukka
Oct 4, 2005·Nature Reviews. Immunology·Kristin A HogquistStephen C Jameson
Oct 11, 2005·Critical Reviews in Oncology/hematology·Torsten HaferlachClaudia Schoch
Dec 6, 2005·Cancer Immunology, Immunotherapy : CII·Koji KonoHideki Fujii
Apr 25, 2006·Immunology·Leonie S TaamsCatherine M Hawrylowicz
Jul 5, 2006·The Journal of Experimental Medicine·Weihong LiuJeffrey A Bluestone
Aug 2, 2007·The Journal of Allergy and Clinical Immunology·Rosa BacchettaMaria-Grazia Roncarolo
Mar 19, 2008·Immunology·Dorothy K SojkaDeborah J Fowell
May 31, 2008·Cell·Shimon SakaguchiMasahiro Ono
Jul 24, 2008·Journal of the National Cancer Institute. Monographs·Joseph Wiemels
May 7, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Miroslaw J SzczepanskiMichael Boyiadzis
Apr 20, 2010·Advances in Cancer Research·Dimitrios MougiakakosC Christian Johansson
Nov 26, 2010·International Journal of Cancer. Journal International Du Cancer·Zhang ShenghuiXu Xi
Apr 15, 2011·Immunological Reviews·Todd C Metzger, Mark S Anderson
Dec 14, 2011·Journal of Hematology & Oncology·Jing Wang, Xiao-Yan Ke
Jan 10, 2012·Annual Review of Immunology·Steven Z JosefowiczAlexander Y Rudensky
Dec 4, 2012·Clinical and Experimental Immunology·K OleinikaA R Fraser
Apr 10, 2014·Immunological Reviews·Ethan M Shevach, Angela M Thornton
Oct 30, 2014·International Journal of Cancer. Journal International Du Cancer·Huanhuan JiangViktor Umansky
Jan 27, 2015·Neuro-oncology·Alissa A ThomasCamilo E Fadul

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Citations

May 31, 2016·Expert Opinion on Biological Therapy·Ming NiAnita Schmitt
Oct 27, 2017·Journal of Pediatric Hematology/oncology·Neda MosakhaniJukka Vakkila
Jul 15, 2018·International Journal of Cancer. Journal International Du Cancer·Susanne HofmannJochen Greiner
Apr 5, 2019·Journal of Immunology Research·M NiedźwieckiP Trzonkowski
Jan 28, 2017·Immunotherapy·Jean-Marc HoffmannAnita Schmitt

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