Increased release of tumour cells by collagenase at acid pH: a possible mechanism for metastasis

G A Turner


The ability of collagenase to disaggregate a solid metastasizing lymphosarcoma has been shown to considerably increase with reducing environmental pH. It is suggested that this effect may be operating in vivo to release cells from a primary tumour.


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Related Concepts

Tumor Cells, Uncertain Whether Benign or Malignant
Lymphoma, Non-Hodgkin
Tumor Lysis Syndrome
Collagenase-Like Peptidase
Neoplasm Metastasis
Hydrogen-Ion Concentration

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