Increased renal neuroleptic binding in spontaneously hypertensive rats

European Journal of Pharmacology
J E RosenblattC B Pert

Abstract

The present experiments demonstrate high affinity stereospecific binding of the dopaminergic ligand [3H]spiroperidol to rat renal membranes. The binding was saturable, regionally distributed, and showed the same specificity as the caudate [3H]spiroperidol site for displacement by dopaminergic antagonists. Since there is an association between hypertension and abnormalities of renal blood flow, which appears to be regulated in part by dopamine, [3H]spiroperidol binding was measured in kidneys of spontaneously hypertensive rats. In two independent experiments renal cortical [3H]spiroperidol stereospecific binding was increased in spontaneously hypertensive rats.

References

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Citations

Jul 15, 1983·Experientia·C Bell
Sep 30, 1983·European Journal of Pharmacology·R ThyagarajanM K Ticku
Jun 1, 1988·Kidney International·M GalbuseraT Mennini
Mar 29, 2001·Clinical and Experimental Hypertension : CHE·F AmentaS K Tayebati
Nov 1, 1982·Hypertension·W H BeierwaltesP J Klemmer
Jan 1, 1988·Journal of Receptor Research·J HietalaM Röyttä

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