PMID: 9826Aug 1, 1976

Increased resistance of an interferon-resistant cell subline to the toxic effect of double-stranded RNA

Acta Virologica
V Lackovic, L Borecký

Abstract

The toxicity of double-stranded (ds) f2-phage RNA for interferon-treated L cells and an interferon-resistant subline of L cells (CVS cells) was compared. The interferon-resistant subline proved to be about 20 times more resistant to ds RNA than the parent L cells. The degree of toxicity of ds RNA was dependent on the concentration of interferon to which the cells were exposed.

Related Concepts

Cell Division Phases
Coliphages
Drug Resistance
Interferons
L Cells (Cell Line)
RNA, Viral

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