PMID: 44208Nov 1, 1979

Increased resistance of (CBAxC57BL/6)Fl hybrids to the graft-versus-host reaction during spleen regeneration

Biulleten' eksperimental'noĭ biologii i meditsiny
R Ia Meshkova

Abstract

Partial splenectomy was performed in CBAXXC57BL/6/F1 hybrids 2, 12, 15 and 20 days before the graft-versus-host reaction induction (GVHR) and 2, 10 days after administration of parenteral immunocompentent cells. The recipients with the intact spleen or complete splenectomy and sham operated recipients served as control. Hybrids with the regenerating spleen were more resistant to GVHR within 12 days of regeneration, while splenectomy increased hybrid resistance to GVHR only when performed 2 days before or 2 days following the GVHR induction.

References

Mar 1, 1985·Biulleten' eksperimental'noĭ biologii i meditsiny·A G Babaeva, E I Gimmel'farb

Citations

Jan 28, 1978·Lancet·J L SullivanR J Wedgwood
Nov 1, 1981·Biulleten' eksperimental'noĭ biologii i meditsiny·R Ia Meshkova, G V Kharlova

Related Concepts

Salicylhydroxamic acid
Spleen
Graft Vs Host Reaction
Parenteral Route of Drug Administration
Hybrids
Natural Regeneration
Spleen Tissue
Hybrid Resistance
Crosses, Genetic
Mice, Inbred Strains

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