Increased resistance of gram-negative urinary pathogens after kidney transplantation

BMC Nephrology
Johannes KorthOliver Witzke

Abstract

Urinary tract infection is the most common complication after kidney transplantation. It can cause severe sepsis and transplant loss. Emergence of drug resistance among gram-negative urinary pathogens is the current challenge for urinary tract infection treatment after kidney transplantation. This study analyzes the antimicrobial susceptibility of gram-negative urinary pathogens after kidney transplantation from 2009 to 2012 at the Transplant Outpatient Clinic of the University Hospital Essen, Germany. Kidney transplant patients at the University Hospital Essen receive regular follow up examinations after transplantation. Midstream urines were examined for bacteriuria at each follow up visit. From 2009 to 2012 15.741 urine samples were obtained from 859 patients. In 2985 (19%) samples bacterial growth was detected. The most frequently detected gram-negative bacteria were E.coli 1109 (37%), Klebsiella spp. 242 (8%) and Pseudomonas aeruginosa 136 (4.5%). Klebsiella spp. showed a significant increase of resistance to trimethoprim-sulfamethoxazole by 19% (p = 0.02), ciprofloxacin by 15% (p = 0.01) and ceftazidime by 17% (p = 0.004). E.coli and P. aeruginosa isolates presented no significant differences of antimicrobial susceptibili...Continue Reading

References

Jun 28, 2005·Antimicrobial Agents and Chemotherapy·P Margreet G FiliusHubert P Endtz
Nov 14, 2006·Transplantation Proceedings·B ValeraJ M Cisneros
Feb 9, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G PelléA Vandewalle
May 26, 2007·Transplantation Proceedings·S S SengerM Haberal
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Vikas R DharnidharkaKevin C Abbott
Dec 28, 2007·International Journal of Antimicrobial Agents·L LyerováV Teplan
Jun 17, 2008·Critical Care : the Official Journal of the Critical Care Forum·Thomas G Slama
Aug 5, 2008·Transplantation Proceedings·M VerouxP Veroux
Feb 5, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ya-Sung YangFeng-Yee Chang
Feb 5, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kalpana GuptaUNKNOWN European Society for Microbiology and Infectious Diseases
Nov 19, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M D BergamascoC S Abboud
Jan 19, 2012·Antimicrobial Agents and Chemotherapy·Guillermo V SanchezJose M Bordon
Dec 15, 2012·BMC Infectious Diseases·Erika Ferraz de GouvêaGuilherme Santoro-Lopes
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R ParasuramanUNKNOWN AST Infectious Diseases Community of Practice
Sep 17, 2013·International Journal of Environmental Research and Public Health·Chang-Ro LeeSang Hee Lee
Jan 15, 2014·Pediatrics·Ming-Horng TsaiYhu-Chering Huang
Jul 2, 2014·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J E GołębiewskaB Rutkowski
Nov 8, 2014·Current Opinion in Infectious Diseases·Ramandeep SinghFrederike J Bemelman
Dec 17, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·X IriartA Berry
Feb 14, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M BodroC Cervera
Aug 4, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M BodroC Cervera
Aug 22, 2015·Transplantation Proceedings·Z AdamskaM Stronka
Feb 26, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gerd Fätkenheuer, Norma Jung
Apr 1, 2016·Journal of Infection in Developing Countries·Yangmin HuHaibin Dai
Apr 19, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J OrigüenJ M Aguado
Jul 5, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J OrigüenJ M Aguado

❮ Previous
Next ❯

Citations

Jan 7, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·N Le BerreC Pulcini
Apr 11, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Julien CoussementUNKNOWN European Renal Association-European Dialysis Transplant Association (ERA-EDTA) Developing Education Scien
Jan 29, 2019·Journal of Nephrology·Marco FiorentinoLoreto Gesualdo
Aug 6, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Alice CorbelCéline Pulcini

❮ Previous
Next ❯

Software Mentioned

Graph Pad Prism

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.