Increased respiratory neural drive and work of breathing in exercise-induced laryngeal obstruction

Journal of Applied Physiology
Emil S WalstedJames H Hull

Abstract

Exercise-induced laryngeal obstruction (EILO), a phenomenon in which the larynx closes inappropriately during physical activity, is a prevalent cause of exertional dyspnea in young individuals. The physiological ventilatory impact of EILO and its relationship to dyspnea are poorly understood. The objective of this study was to evaluate exercise-related changes in laryngeal aperture on ventilation, pulmonary mechanics, and respiratory neural drive. We prospectively evaluated 12 subjects (6 with EILO and 6 healthy age- and gender-matched controls). Subjects underwent baseline spirometry and a symptom-limited incremental exercise test with simultaneous and synchronized recording of endoscopic video and gastric, esophageal, and transdiaphragmatic pressures, diaphragm electromyography, and respiratory airflow. The EILO and control groups had similar peak work rates and minute ventilation (V̇e) (work rate: 227 ± 35 vs. 237 ± 35 W; V̇e: 103 ± 20 vs. 98 ± 23 l/min; P > 0.05). At submaximal work rates (140-240 W), subjects with EILO demonstrated increased work of breathing ( P < 0.05) and respiratory neural drive ( P < 0.05), developing in close temporal association with onset of endoscopic evidence of laryngeal closure ( P < 0.05). Une...Continue Reading

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Citations

Mar 9, 2018·Current Opinion in Otolaryngology & Head and Neck Surgery·Jemma HainesStephen J Fowler
Dec 21, 2018·American Journal of Respiratory and Critical Care Medicine·James H HullGuri Sandhu
Nov 6, 2018·Psychological Reports·Patrícia Tatiana SolerHelder Miguel Fernandes
Nov 21, 2019·Movement Disorders Clinical Practice·Céleste ReboursMarie Mailly
Mar 16, 2019·Respiratory Physiology & Neurobiology·Valérie AttaliThomas Similowski
Dec 15, 2020·Medicine and Science in Sports and Exercise·Tommie IrewallNikolai Stenfors
Nov 26, 2021·Physiological Reports·Astrid Haugen LieHege H Clemm

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