PMID: 6408674Jan 1, 1983Paper

Increased response switching, perseveration and perseverative switching following d-amphetamine in the rat

Psychopharmacology
J L Evenden, T W Robbins

Abstract

Four experiments examined the effects of d-amphetamine on response switching and perseveration in apparatus allowing a choice of response location. The relative 'cost' of a switch between two response locations and repetitive responding at a single location by rats was manipulated in the various test settings to provide baseline probabilities of switching. d-Amphetamine (0.2-2.3 mg/kg) increased response switching. This effect did not depend on switching being necessary to produce reinforcement and was not explained by increases in locomotor activity, motivational change or randomisation of responding. Further evidence was provided in support of a 'probability-dependency' hypothesis, that the effect of the drug depends in part upon the baseline probability of a response. A measure of perseveration independent of response switching (extra responses made prior to the collection of food) showed that increased switching and increased perseveration occurred in the same situation at the same doses, although perseveration generally occurred at higher doses than increased switching. Therefore the effect of amphetamine on response switching or repetition depends on the dose of drug, the context of the response and its probability of occ...Continue Reading

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Citations

Oct 13, 2006·Psychopharmacology·Yael NivPeter Dayan
Jan 1, 1988·Journal of Psychiatric Research·N Lyon, J Gerlach
May 1, 1986·Pharmacology, Biochemistry, and Behavior·P J CogginsJ A Edwardson
Mar 1, 1987·Pharmacology, Biochemistry, and Behavior·L Kokkinidis
May 1, 1991·Pharmacology, Biochemistry, and Behavior·K Antoniou, E Kafetzopoulos
May 1, 1993·Pharmacology, Biochemistry, and Behavior·R L Corwin, C R Schuster
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·R D Oades
Nov 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·M P PaulusD L Braff
Oct 1, 1994·Progress in Neurobiology·R M Ridley
Aug 1, 1997·Physiology & Behavior·F S HallT W Robbins
Oct 19, 2002·Behavioural Brain Research·Joseph P Garner, Georgia J Mason
Mar 21, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marco BortolatoGian L Gessa
Oct 25, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vasileios BoulougourisTrevor W Robbins
Apr 2, 1999·The European Journal of Neuroscience·D S ZahmJ R Martin
Nov 1, 1992·Biological Reviews of the Cambridge Philosophical Society·S B Dunnett, T W Robbins
Jun 4, 2011·PLoS Computational Biology·Mehdi KeramatiPayam Piray
Jul 1, 2008·Cognitive, Affective & Behavioral Neuroscience·Michael X Cohen
Nov 1, 1984·Pharmacology, Biochemistry, and Behavior·J S Andrews, A Sahgal
Aug 26, 2000·Behavioral Neuroscience·Tyler W FeolaJerry B Richards
Mar 1, 1989·Hormones and Behavior·A van HestN E van de Poll
Oct 7, 2006·Behavioural Processes·Matthew S Matell, George S Portugal
Oct 26, 2005·Behavioural Processes·Matthew S MatellJ Wayne Aldridge

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