Increased responsiveness of human pulmonary arteries in patients with positive bronchodilator response

British Journal of Pharmacology
E CasesS Lluch

Abstract

1. The effects of noradrenaline, endothelin-1, acetylcholine and sodium nitroprusside were studied in isolated pulmonary arteries obtained from 14 patients undergoing lobectomy for lung carcinoma. Seven patients had shown increased response to a bronchodilator test prior to operation. In the remaining patients (control) the bronchodilator test was negative. 2. Artery rings from patients with a positive bronchodilator response showed greater contraction to noradrenaline (pD2 = 6.44 +/- 0.1; Emax = 93 +/- 9% of response to 100 mM KCl) and endothelin-1 (pD2 = 8.92 +/- 0.1; Emax = 130 +/- 16%) than the rings from control patients (pD2 = 6.04 +/- 0.08; Emax = 56 +/- 8% for noradrenaline; pD2 = 8.29 +/- 0.1; Emax = 78 +/- 10% for endothelin-1). There was no significant difference in the contractile responses to 100 mM KCl between arteries from either group of patients. 3. Arterial rings from patients with a positive bronchodilator test achieved 96 +/- 3% of maximal relaxation in response to acetylcholine, whereas rings from control patients achieved a maximal relaxation of 72 +/- 5%. Rings from both the controls and the patients with a positive bronchodilator test achieved complete relaxation in response to sodium nitroprusside but p...Continue Reading

References

Feb 1, 1991·British Journal of Pharmacology·K O McKayC L Armour
May 30, 1991·The New England Journal of Medicine·A T Dinh-XuanJ Wallwork
Dec 1, 1989·Clinical Science·J B WarrenP J Barnes
Jul 1, 1986·The Journal of Clinical Investigation·F Murad
Aug 1, 1988·The American Review of Respiratory Disease·R E DalesS Suissa
Aug 1, 1995·The European Respiratory Journal·C MartínezS Lluch

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Citations

May 19, 2005·European Journal of Pharmacology·Britt ElmedalUlf Simonsen
Sep 12, 2013·BioMed Research International·Priyadharshanan AriyaratnamAlyn H Morice
Jun 9, 2004·American Journal of Respiratory and Critical Care Medicine·Margrid B SchindlerSheila G Haworth
Jan 12, 2007·Cardiovascular Drug Reviews·Britt Elmedal LaursenUlf Simonsen
Feb 22, 2017·The Open Cardiovascular Medicine Journal·A HussainA Morice
Feb 2, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Christel KroigaardUlf Simonsen

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