Increased risk for opportunistic infections during chemotherapy in HIV-infected patients with Kaposi's sarcoma

Dermatology : International Journal for Clinical and Investigative Dermatology
A PlettenbergW Meigel

Abstract

Kaposi's sarcoma (KS) is the most frequent neoplasm in patients with AIDS, responsible for death in about 20-30% of the affected patients. To determine the frequency of opportunistic infections (OI) and change of CD4+ cell counts in patients with KS treated with chemotherapy compared to a group of matched-pair patients without chemotherapy. In a prospective study, the clinical courses of 35 HIV-infected patients with KS treated with chemotherapy were compared with 35 matched-pair patients without chemotherapy. During the observation period of 6 months, 11 OI occurred in 10 patients of the chemotherapy group and 5 OI in 5 patients of the control group. With respect to the changes of CD4+ cell counts, no significant differences could be observed. The risk for OI in HIV-infected patients with KS is increased while receiving chemotherapy. This should be reflected upon when chemotherapy is taken into consideration.

Citations

Apr 6, 1999·Cancer Treatment Reviews·G SchwartsmannR U Villarroel
Mar 10, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C W YangB K Bang
May 21, 1998·Antimicrobial Agents and Chemotherapy·J A Fishman

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