Abstract
Studies on the association between leptospirosis and acute coronary syndrome (ACS) are lacking. Therefore, this study identifies the effects of leptospirosis on the risks of developing ACS with a nationwide retrospective cohort study. We identified adult patients aged ≥20 years who were newly diagnosed with leptospirosis. We also randomly selected a comparison cohort from the general population by using a propensity score matching method. We analyzed the risks of ACS by using Cox proportional hazard regression models. Among the 23.74 million people in the cohort, 3690 patients with leptospirosis (68% men, mean age of 52.2 years) and 3690 controls were followed for 13,677 and 15,652 person-years, respectively. The overall incidence of ACS was higher in the leptospirosis cohort than in the nonleptospirosis cohort (4.68 vs 3.71 per 1000 person-years), with a hazard ratio (HR) of 1.69 (95% confidence interval [CI]=1.12-2.56). Men exhibited a 1.88-fold greater HR of ACS than women did (95% CI=1.20-2.94). The risk of developing ACS was highest for leptospirosis patients aged ≥65 years (HR=7, 51% CI=4.35-12.9) compared with patients aged ≤49 years. Leptospirosis is not a previously identified risk factor for ACS. The findings of this ...Continue Reading
References
Dec 16, 1998·The Journal of Emergency Medicine·W D Binder, L A Mermel
Jan 17, 2003·Journal of Internal Medicine·A ReunanenA Aromaa
Apr 16, 2003·Kidney International. Supplement·Jan GalleChristoph Wanner
May 7, 2003·Preventive Cardiology·Christina ChrysohoouPavlos K Toutouzas
Oct 8, 2003·Circulation·Morteza NaghaviJames T Willerson
Jun 9, 2004·Circulation·Marcel LeviHarry R Büller
Jun 17, 2004·Circulation·Jean Davignon, Peter Ganz
Mar 26, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christine M ArcariKenrad E Nelson
Mar 30, 2005·Circulation·Brian R ClappAroon D Hingorani
Aug 23, 2005·Proceedings of the American Thoracic Society·Don D Sin, S F Paul Man
Nov 12, 2005·British Journal of Haematology·Charles T Esmon
Mar 17, 2007·Annals of Medicine·Kjell C NikusKari O Niemelä
Jun 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel M MusherSulaiman M Mapara
Feb 28, 2008·Current Opinion in Pulmonary Medicine·Don D Sin, S F Paul Man
Oct 30, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Omer AlyanErdogan Ilkay
Jul 16, 2010·Lipids in Health and Disease·Dagmar VondrakovaAndreas Kruger
Aug 4, 2010·Autoimmunity Reviews·S SitiaM Turiel
Sep 24, 2010·Future Microbiology·Karen V Evangelista, Jenifer Coburn
Jul 13, 2011·International Journal of Hypertension·Claudio PicarielloSerafina Valente
Oct 11, 2012·The Journal of Infectious Diseases·Charlotte Warren-GashLiam Smeeth
Nov 8, 2012·Mediators of Inflammation·C F Gonçalves-de-AlbuquerqueM V Castro-Faria
Mar 6, 2013·JAMA Internal Medicine·Matthew S FreibergAmy C Justice
Oct 15, 2013·Statistics in Medicine·Peter C Austin
Citations
Apr 12, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Chin-Tun HungWei-Sheng Chung
Sep 28, 2018·Human Vaccines & Immunotherapeutics·Cuicai ZhangQiang Ye
Sep 5, 2019·International Journal of Environmental Research and Public Health·Chun-Hsiang ChiuKuang-Hsi Chang
May 20, 2016·Medicine·Ming-Tse HsuWei-Sheng Chung
Mar 18, 2016·Medicine·Chun-Hsiang ChiuChia-Hung Kao
Jan 27, 2021·Stroke; a Journal of Cerebral Circulation·Kuan-Ying LiRenin Chang