Abstract
In utero exposure to maternal antibodies and cytokines are potential risk factors for autism spectrum disorders (ASDs). The aim of this study was to determine whether children born to mothers with systemic lupus erythematosus (SLE) have an increased risk of ASD compared to children born to mothers without SLE. The study population was derived from the Offspring of SLE Mothers Registry (OSLER), a large population-based cohort identified through healthcare databases in Quebec (1989-2009) comprising all women who had ≥1 hospitalization for a delivery (stillbirth or live birth) after SLE diagnosis. As general population controls, a randomly selected group of women without SLE was matched ≥4:1 to the mothers with SLE for age and year of delivery. Children born live to mothers with SLE and those born live to matched controls were identified, and a recorded diagnosis of ASD was ascertained for each child. Multivariate analyses were performed to adjust for parents' demographic characteristics, sex, birth order of the child, maternal comorbidities, and obstetric complications. In total, 509 women with SLE had 719 children, and 5,824 matched controls had 8,493 children. Children born to women with SLE were more frequently found to have a...Continue Reading
References
Jan 1, 1988·Psychoneuroendocrinology·R G Lahita
Aug 1, 1995·Journal of Clinical Epidemiology·R TamblynJ Monette
Feb 1, 1995·American Journal of Epidemiology·L JosephL Coupal
May 1, 1996·Molecular and Chemical Neuropathology·R P WarrenW L Warren
Oct 20, 1998·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M NavesW E Ollier
Mar 17, 2001·Biometrics·N Dendukuri, L Joseph
Aug 3, 2001·Pediatrics·M S KramerUNKNOWN Fetal/Infant Health Study Group of the Canadian Perinatal Surveillance System
Jul 3, 2002·Epidemiology·Christina M HultmanSven Cnattingius
Dec 12, 2002·Lupus·S ShrotJ Chapman
Apr 16, 2003·Archives of Pediatrics & Adolescent Medicine·Gail RossMichael Lockshin
May 6, 2004·Journal of Clinical Epidemiology·Machelle WilcheskyAllen Huang
Nov 16, 2004·Lupus·F NeriA Tincani
Feb 8, 2005·Human Immunology·Dennis OdellAnthony Torres
Dec 24, 2005·Pharmacoepidemiology and Drug Safety·Lucie BlaisDjamal Berbiche
Aug 26, 2006·American Journal of Epidemiology·Sonia Hernández-DíazMiguel A Hernán
Nov 1, 2006·Arthritis and Rheumatism·Megan E B ClowseMichelle Petri
Nov 23, 2007·Rheumatology·S BernatskyA E Clarke
Feb 14, 2008·Pharmacoepidemiology and Drug Safety·Anne VilainLucie Blais
Jun 10, 2008·Lupus·M B UrowitzE Silverman
Dec 3, 2008·Neurology·R L BromleyUNKNOWN Liverpool and Manchester Neurodevelopment Group
Dec 17, 2008·Nature Medicine·Ji Y LeeBetty Diamond
Feb 17, 2009·Pediatric Research·Eric Fombonne
Apr 12, 2012·Pediatrics·Paula KrakowiakIrva Hertz-Picciotto
Jun 9, 2012·The Journal of Pediatrics·Katja M LampiAndre Sourander
Jun 13, 2012·Archives of Neurology·Daniel Braunschweig, Judy Van de Water
Nov 10, 2012·Arthritis Care & Research·Wendy MarderEmily C Somers
Sep 3, 2013·Neuroscience·H WeiX Li
Sep 27, 2013·JAMA Psychiatry·Brian M D'OnofrioPaul Lichtenstein
Oct 29, 2013·The Journal of Pediatrics·Michael W KuzniewiczLisa A Croen
Citations
Jan 5, 2016·Journal of Autoimmunity·Lauren Matelski, Judy Van de Water
Jul 28, 2016·Frontiers in Neuroscience·Asher OrnoyZivanit Ergaz
Jul 28, 2016·Frontiers in Neuroscience·Stefano Nardone, Evan Elliott
Apr 11, 2017·Lupus·C NalliA Tincani
Apr 7, 2017·Developmental Medicine and Child Neurology·Ori ScottHelly R Goez
Apr 19, 2017·The Journal of International Medical Research·William ParkerCynthia D Nevison
Mar 21, 2017·Arthritis Care & Research·Sophie WojcikÉvelyne Vinet
Jul 28, 2016·Annals of the Rheumatic Diseases·L AndreoliA Tincani
Nov 16, 2018·Birth Defects Research·Elena Minakova, Barbara B Warner
Dec 29, 2018·Congenital Anomalies·Tsuyoshi TsukadaToshihisa Hatta
Nov 2, 2019·Molecular Autism·Charles E MordauntM Daniele Fallin
Jun 12, 2020·Brain Sciences·Kimon RungeDominique Endres
May 7, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Galen MissigWilliam A Carlezon
Jun 14, 2019·Frontiers in Immunology·Adriana Gata-Garcia, Betty Diamond
Jul 9, 2020·Neuropsychiatric Disease and Treatment·Regina SalaPaul Whiteley
Aug 19, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amory Meltzer, Judy Van de Water
Aug 24, 2018·Rheumatology·Evelyne VinetMegan E B Clowse
Sep 4, 2020·Scientific Reports·Ciara Bagnall-MoreauLior Brimberg
Mar 14, 2020·Clinical Neuropharmacology·Malekfarhad MalekShahin Akhondzadeh
Feb 9, 2020·Journal of Autism and Developmental Disorders·Zhixian ZhuYing Wang
Feb 23, 2020·Molecular Psychiatry·N R ZürcherJ M Hooker
Jan 5, 2021·Frontiers in Pharmacology·Maria-Grazia LazzaroniAngela Tincani
Oct 31, 2020·Medicine·Hiromi ShimadaHiroaki Dobashi
Feb 19, 2021·Expert Opinion on Drug Safety·Anna Viola TaulaigoLaura Andreoli
Mar 17, 2021·Clinical Reviews in Allergy & Immunology·Laura AndreoliAngela Tincani
Mar 31, 2021·Current Rheumatology Reports·Aida ZarfeshaniBetty Diamond
Apr 3, 2020·Autoimmunity Reviews·Cristina BeliznaLaura Andreoli
May 21, 2021·Lupus·Takehiro NakaiMasato Okada
Jul 3, 2021·Journal of Clinical Medicine·Dora DavidovGali Pariente
Feb 5, 2021·Clinical and Experimental Pediatrics·Ensiyeh JenabiMahdieh Seyedi