Abstract
Hidradenitis suppurativa (HS) has been reported to be associated with metabolic syndrome and coronary artery disease (CAD). Nevertheless, a nationwide study of this relationship in the Asian population has not been conducted. The aim of the present study was to clarify the cardiovascular disease risk factors, and the occurrence of CAD and cerebral infarction among patients with HS by using a nationwide database in Taiwan. We obtained data from the National Health Insurance Research Database of Taiwan. After adjusting for confounding factors, we used Cox proportional hazards analysis to reveal the risk of incident hypertension (HTN), diabetes mellitus (DM), dyslipidemia, CAD and cerebral infarction in HS patients. We identified 478 patients with newly diagnosed HS and 1912 patients in the control cohort during the 10-year follow-up period. Compared with the controls, HS patients had a higher risk of dyslipidemia (adjusted hazard ratio [aHR], 3.858; 95% confidence interval [CI], 2.785-5.346; P < 0.001), HTN (aHR, 1.910; 95% CI, 1.463-2.493; P < 0.001), DM (aHR, 1.709; 95% CI, 1.127-2.591; P = 0.012). Regarding comorbidities, our results also revealed a higher risk of CAD in HS patients (aHR, 2.722; 95% CI, 1.628-4.553; P < 0.001)...Continue Reading
References
Jun 1, 1990·The British Journal of Dermatology·C C Yu, M G Cook
Jun 1, 1996·Journal of the American Academy of Dermatology·G B Jemec, U Hansen
Nov 1, 1996·The British Journal of Dermatology·J Boer, E F Weltevreden
Jul 15, 2005·Journal of Critical Care·Dale M NeedhamPeter J Pronovost
Jan 5, 2007·Journal of Lipid Research·Calin PopaAnton F H Stalenhoef
Mar 19, 2009·Journal of the American Academy of Dermatology·Ali AlikhanDaniel B Eisen
Aug 8, 2009·Experimental Dermatology·Maximilian von LaffertWolfgang Christian Marsch
Dec 10, 2009·Acta Dermato-venereologica·Lukasz MatusiakJacek C Szepietowski
Feb 22, 2011·The British Journal of Dermatology·H H van der ZeeE P Prens
Feb 26, 2011·Pharmacoepidemiology and Drug Safety·Ching-Lan ChengMing Liang Lai
Jun 7, 2011·Journal of the American Academy of Dermatology·Christoph SchlapbachRobert E Hunger
Jan 13, 2012·The New England Journal of Medicine·Gregor B E Jemec
Feb 24, 2012·PloS One·Robert SabatWolfram Sterry
Jan 18, 2014·Journal of the American Academy of Dermatology·Daniel A GoldIltefat H Hamzavi
Apr 10, 2014·The British Journal of Dermatology·G E KimA B Kimball
Aug 6, 2014·Nature Reviews. Rheumatology·György KerekesZoltán Szekanecz
Sep 18, 2014·JAMA Dermatology·Iben Marie MillerGregor B E Jemec
Mar 12, 2015·The British Journal of Dermatology·G ShalomA D Cohen
Aug 21, 2015·International Journal of Cardiology·Ching-Lan ChengYea-Huei Kao Yang
Oct 6, 2015·The British Journal of Dermatology·A L LimaB Bauer
Oct 17, 2015·Journal of the American Academy of Dermatology·Gregor B E Jemec, Alexa B Kimball
Oct 17, 2015·Journal of the American Academy of Dermatology·Errol Prens, Inge Deckers
Oct 17, 2015·Journal of the American Academy of Dermatology·Robert A Lee, Daniel B Eisen
Feb 18, 2016·JAMA Dermatology·Alexander EgebergPeter R Hansen
Jan 4, 2017·Journal of the American Academy of Dermatology·Łukasz MatusiakJacek C Szepietowski
Feb 27, 2017·Trends in Cell Biology·Leen Catrysse, Geert van Loo
May 12, 2017·JAMA Dermatology·Amit GargAndrew Strunk
Jun 2, 2017·Journal of Cellular Biochemistry·Muhammad Sajid Hamid AkashAamira Liaqat
Jul 19, 2017·PloS One·Sanminder SinghApril W Armstrong
Nov 3, 2017·The British Journal of Dermatology·J R IngramV Piguet
Sep 13, 2018·Postȩpy dermatologii i alergologii·Magdalena PirowskaAnna Wojas-Pelc
Nov 10, 2018·Skin Appendage Disorders·Ellie ChoiNisha Suyien Chandran
Citations
Jul 23, 2020·Cardiovascular Therapeutics·Nevena SkrozaConcetta Potenza
Oct 11, 2020·Journal of the American Academy of Dermatology·Adrian Michel Joseph BaileyMark G Kirchhof
Jun 3, 2021·International Journal of Dermatology·Ryan Daniel GotesmanAfsaneh Alavi
Jul 23, 2021·The Journal of Dermatological Treatment·Kevin PhanSaxon D Smith
Jan 22, 2021·Dermatology : International Journal for Clinical and Investigative Dermatology·Carlos Cuenca-BarralesAlejandro Molina-Leyva