Increased risk of chronic fatigue syndrome in patients with inflammatory bowel disease: a population-based retrospective cohort study

Journal of Translational Medicine
Shin-Yi TsaiTse-Yen Yang

Abstract

Similarities in the symptoms of chronic fatigue syndrome (CFS) and inflammatory bowel disease (IBD) have been observed as follows: severe disease activity in IBD correlates with severe fatigue, major psychiatric signs, the common use of medication, and bacterial translocation. One of several hypotheses for explaining the mechanisms underlying CFS suggests a similarity to the impaired intestinal mucosa of IBD. "This study investigated the risk of incident CFS among patients with IBD". We conducted a population-based retrospective cohort study by using Taiwan's National Health Insurance Research Database to evaluate the subsequent risk of CFS in patients with IBD, according to demographic characteristics and comorbidities. The exposure cohort comprised 2163 patients with new diagnoses of IBD. Each patient was randomly selected and frequency matching according to gender and age with four participants from the general population who had no history of CFS at the index date (control cohort). Cox proportional hazards regression analysis was conducted to estimate the relationship between IBD and the subsequent risk of CFS. The exposure cohort had a significantly higher overall risk of subsequent CFS than that of the control group [adju...Continue Reading

References

Nov 3, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·A KorszunL Crofford
May 11, 2001·Annals of Internal Medicine·L A Aaron, D Buchwald
Jun 18, 2003·The American Journal of Gastroenterology·Itta M MinderhoudGerard P van Berge Henegouwen
Jul 16, 2008·Inflammatory Bowel Diseases·Michael A McGuckinGraham Radford-Smith
Jan 9, 2009·Inflammatory Bowel Diseases·Christine P DanceyAmanda Sonnet
Nov 20, 2009·The New England Journal of Medicine·Clara Abraham, Judy H Cho
Mar 18, 2010·Nature Reviews. Neurology·V Hugh PerryClive Holmes
Sep 20, 2011·BMC Health Services Research·Simon M CollinUNKNOWN UK CFS/ME National Outcomes Database
Jan 10, 2012·Psychosomatics·Elizabeth J DansiePatrick F Sullivan
Apr 3, 2012·Inflammatory Bowel Diseases·George P ChristophiSteve K Landas
Apr 23, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lesley A GraffCharles N Bernstein
Apr 10, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S-Y TsaiC-H Kao
Aug 28, 2014·International Journal of Surgery·Gianluca PellinoFrancesco Selvaggi
Dec 17, 2014·Pediatric Surgery International·Fatma SaracAyse Saygili
Jan 11, 2017·The American Journal of Gastroenterology·Francis A FarrayeSunanda V Kane
Dec 7, 2018·Journal of Translational Medicine·Shin-Yi TsaiLeiyu Shi
Dec 24, 2018·Systematic Reviews·S Du PreezS Marshall-Gradisnik

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Citations

May 16, 2019·Journal of Translational Medicine·Shin-Yi TsaiWei-Sheng Wang
Oct 3, 2019·Nutrients·Ulrike HaßKristina Norman
Jul 25, 2019·Diagnostics·Daniel MissailidisPaul R Fisher
Jul 13, 2021·Frontiers in Cellular Neuroscience·Adonis SferaZisis Kozlakidis
Aug 8, 2021·Journal of Clinical Medicine·Leiyu ShiShin-Yi Tsai

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Methods Mentioned

BETA
bacterial translocation

Software Mentioned

SAS

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