Increased risk of colon cancer associated with a genetic polymorphism of SMAD7.

Cancer Research
Martha L SlatteryUlrike Peters

Abstract

Genome-wide association studies (GWAS) have identified SMAD7 on 8q21 as being associated with colorectal cancer. We evaluated single nucleotide polymorphisms (SNP) in the SMAD7 gene, including rs4939827, rs12953717, and rs4464148, previously identified from GWAS in a large population-based case-control study of colon cancer. We observed that rs12953717 was associated with a statistically significant increased risk of colon cancer [odds ratio, 1.38; 95% confidence intervals (CI), 1.13-1.68; P linear trend < 0.01] for the TT genotype compared with the CC genotype, whereas the CC genotype of the rs4939827 SNP was inversely associated with colon cancer (0.77; 95% CI, 0.64-0.93) relative to the TT genotype. There were no significant differences in association for either of these polymorphisms when stratified by age, tumor site, sex, or family history. The odds ratios between SMAD7 and colon cancer among individuals reporting recent aspirin/nonsteroidal anti-inflammatory drug use was 0.60 (95% CI, 0.43-0.85) for the CC genotype of the rs4939827 polymorphism and 1.69 (95% CI, 1.20-2.38) for the TT genotype of the rs1295371 polymorphism. This result compares to odds ratios of 0.86 (95% CI, 0.68-1.09) for rs4939827 and 1.22 (95% CI, 0.9...Continue Reading

References

Jul 1, 1994·Journal of the American Dietetic Association·M L SlatteryR Kerber
Feb 1, 1997·Annals of Epidemiology·M L SlatteryJ D Potter
Mar 21, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·B J CaanS M Edwards
May 21, 1999·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·C La VecchiaS Franceschi
Nov 18, 2000·Journal of the National Cancer Institute·M L SlatteryW S Samowitz
May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Wade S SamowitzMartha L Slattery
Feb 14, 2003·International Journal of Cancer. Journal International Du Cancer·Jean-Louis BoulayChristoph Rochlitz
Jul 29, 2003·American Journal of Epidemiology·M L SlatteryD Schaffer
Mar 31, 2004·Sports Medicine·Martha L Slattery
May 8, 2004·Trends in Biochemical Sciences·Peter ten Dijke, Caroline S Hill
Jun 1, 2005·Experimental Cell Research·Sunil K HalderPran K Datta
Aug 23, 2006·Human Molecular Genetics·Zoe KempUNKNOWN ColoRectal tumour Gene Identification (CoRGI) Study Consortium
Sep 5, 2006·Developmental Cell·Sarah E Millar
Nov 11, 2006·International Journal of Cancer. Journal International Du Cancer·Martha L SlatteryWade S Samowitz
Jan 22, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Karen CurtinUNKNOWN Colorectal Cancer Study Group

❮ Previous
Next ❯

Citations

Jul 23, 2013·Medical Oncology·Zhen-Bin MaGuang-Hong Guo
Jan 12, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shuji OginoEdward Giovannucci
Nov 12, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Martha L SlatteryRoger K Wolff
Dec 30, 2011·Cell & Bioscience·Lu ZhuYan Chen
Jul 8, 2011·Future Oncology·Katayoon Kasaian, Steven Jm Jones
Dec 10, 2013·International Journal of Molecular Sciences·Carmine StolfiGiovanni Monteleone
Nov 17, 2012·World Journal of Gastroenterology : WJG·Giovanni MonteleoneFrancesco Pallone
Aug 21, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yanliang HuJinjie Zhang
Feb 22, 2014·Cell Death & Disease·C StolfiG Monteleone
Apr 15, 2011·Journal of Biomedicine & Biotechnology·Lucia MiglioreFabio Coppedè
Jun 18, 2014·The American Journal of Gastroenterology·Paul LochheadShuji Ogino
Jan 15, 2016·British Journal of Cancer·Xabier Garcia-AlbenizJenny Chang-Claude
Jun 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Zahra AkbariMohammad Reza Zali
Nov 6, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qingchao TangXishan Wang
Jun 18, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lingyu LuoDeqiang Huang
Jun 14, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Paul LochheadShuji Ogino
Dec 7, 2016·Cold Spring Harbor Perspectives in Biology·Keiji Miyazawa, Kohei Miyazono
Apr 5, 2017·Journal of Clinical Laboratory Analysis·Olfat Gamil ShakerZeinab Mahmoud
Aug 30, 2017·Journal of Cancer Research and Clinical Oncology·Makiko AbeKeitaro Matsuo
Sep 5, 2017·Oncogene·P ChandrasingheJ Warusavitarne
Dec 5, 2015·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Satoyo HosonoKeitaro Matsuo
Mar 10, 2011·International Journal of Cancer. Journal International Du Cancer·Martha L SlatteryRoger K Wolff
Jul 24, 2013·Journal of Gastroenterology and Hepatology·Sung Noh HongYoung-Ho Kim
Dec 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Mohammadreza NassiriMohammad Doosti
Feb 3, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Behzad DamavandMohammad Reza Zali
Dec 1, 2018·Mediators of Inflammation·Amal Ahmed Abd El-FattahAmal Mohamed Kamal
Dec 31, 2020·Biomolecules·Carmine StolfiGiovanni Monteleone
Jan 30, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Frank ReillyPatrick Ronan O'Connell
May 1, 2021·International Journal of Molecular Sciences·Edoardo TronconeGiovanni Monteleone

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Martha L SlatteryJohn D Potter
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Karen CurtinMartha L Slattery
© 2021 Meta ULC. All rights reserved