Increased risk of cutaneous melanoma associated with p53 Arg72Pro polymorphism

PloS One
Peiliang GengHoujie Liang

Abstract

The objective of this study was to test the hypothesis that p53 Arg72Pro polymorphism may contribute to an increased risk of cutaneous melanoma (CM). By searching the databases of PubMed, EMBASE, and Web of Science, a total of 8 eligible case-control studies with 1,957 CM cases and 2,887 controls were included in this meta-analysis. Stata software was used to analyze all the statistical data. The pooled data by a fixed-effects model suggested an increased risk of CM associated with p53 Arg72Pro polymorphism under the genetic model of Arg/Pro vs. Pro/Pro without heterogeneity (ORArg/Pro vs. Pro/Pro = 1.76, 95% CI = 1.55-1.99, Pheterogeneity = 0.075). A similar trend was seen in subgroups of hospital-based studies and population-based studies. Our meta-analysis based on all studies shows that the p53 Arg72Pro polymorphism may increase individual susceptibility to CM, particularly in Caucasians and could serve as a biomarker to predict the population at high risk of CM.

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Feb 12, 1998·Annals of Internal Medicine·J LauC H Schmid
Aug 6, 1999·Oncogene·W JiangM L Kripke
Jan 5, 2000·Oncogene·W G Kaelin
Feb 27, 2001·Current Opinion in Oncology·S Halachmi, B A Gilchrest
Mar 20, 2001·Molecular Carcinogenesis·M T BastiaensJ ter Schegget
Nov 16, 2001·Archives of Dermatology·A M Goldstein, M A Tucker
Dec 26, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F BrayD M Parkin
Jan 5, 2002·Acta Oncologica·A I Robles, C C Harris
Apr 23, 2002·The British Journal of Dermatology·Jean-Paul Ortonne
May 15, 2002·Human Mutation·Magali OlivierPierre Hainaut
Sep 20, 2002·Skin Pharmacology and Applied Skin Physiology·Frank R de Gruijl
Feb 5, 2003·Nature Genetics·Patrick DumontMaureen Murphy
Dec 17, 2003·The Journal of Investigative Dermatology·Hongbing ShenQingyi Wei
Aug 12, 2005·International Journal of Cancer. Journal International Du Cancer·Christian GwosdzVera Balz
Jun 2, 2006·Molecular Carcinogenesis·Jiali HanDavid J Hunter
Feb 3, 2007·Toxicology and Applied Pharmacology·Cara L Benjamin, Honnavara N Ananthaswamy
Mar 20, 2008·Advances in Experimental Medicine and Biology·Cara L BenjaminHonnavara N Ananthaswamy
Jan 24, 2009·Nature Reviews. Cancer·Catherine WhibleyMonica Hollstein
Jul 9, 2010·CA: a Cancer Journal for Clinicians·Ahmedin JemalElizabeth Ward
Sep 24, 2010·The Journal of Investigative Dermatology·De-Ke JiangLong Yu
Dec 31, 2010·The Journal of Investigative Dermatology·Yan-Feng ZouXiao-Liang Feng
Nov 26, 2011·Journal of Biosciences·Helena S ThurowFabiana K Seixas
Feb 18, 2012·The Journal of Investigative Dermatology·Javier CotignolaIrene Orlow
Apr 10, 2013·Journal of Cancer Research and Clinical Oncology·Cristiane OliveiraCarmen Silvia Passos Lima

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Methods Mentioned

BETA
genotyping

Software Mentioned

Stata

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