Increased risk of dementia among patients with pulmonary tuberculosis: a retrospective population-based cohort study

American Journal of Alzheimer's Disease and Other Dementias
Yi-Hao PengChia-Hung Kao

Abstract

We investigated and compared the risk of dementia development in a cohort of patients with tuberculosis (TB). The study involved 6473 patient with newly diagnosed TB, and each patient was randomly frequency matched with 4 people without TB based on age, sex, and index year. The risk of dementia development was analyzed using Cox proportional hazards regression. Among the patients with TB, the overall risk of developing dementia was 1.21-fold significantly higher than the non-TB cohort. In the stratified analysis of dementia risks, only the patients with TB who were male or 50 to 64 years of age exhibited a significantly higher risk of dementia development compared with those without TB. An analysis of the follow-up duration revealed that patients with TB had a 1.78-fold increased risk within 1 year of follow-up. Patients with TB have a significantly higher risk of developing dementia than that of the general population.

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