Increased Risk of Depression Recurrence After Initiation of Prescription Opioids in Noncancer Pain Patients

The Journal of Pain : Official Journal of the American Pain Society
Jeffrey F ScherrerPatrick J Lustman

Abstract

Several studies have shown that chronic opioid analgesic use is associated with increased risk of new-onset depression. It is not known if patients with remitted depression are at increased risk of relapse after exposure to opioid analgesics. A retrospective cohort design using patient data from the Veterans Health Administration (VHA; n = 5,400), and Baylor Scott & White Health (BSWH; n = 842) was performed with an observation period in the VHA from 2002 to 2012 and in the BSWH from 2003 to 2012. Eligible patients had a diagnosis of depression at baseline and experienced a period of remission. Risk of depression recurrence was modeled in patients that either started taking an opioid or continued without opioid prescriptions before or during remission. Cox proportional hazard models were used to measure the association between opioid use and depression recurrence controlling for pain, and other confounders. Patients exposed to an opioid compared with those unexposed had a significantly greater risk of depression recurrence in both patient populations (VHA: hazard ratio [HR] = 2.17, 95% confidence interval [CI], 2.01-2.34; BSWH: HR = 1.77; 95% CI, 1.42-2.21). These results suggest opioid use doubles the risk of depression recurr...Continue Reading

References

Jun 1, 1997·The Clinical Journal of Pain·D A FishbainR S Rosomoff
Oct 31, 2003·Expert Reviews in Molecular Medicine·Stephen V FaraoneMing T Tsuang
Aug 12, 2005·The Clinical Journal of Pain·S Hakki OnenClaude Dubray
Jul 20, 2006·American Journal of Medical Quality : the Official Journal of the American College of Medical Quality·Leif I SolbergPatrick J O'Connor
Oct 25, 2006·Archives of Internal Medicine·Mark D SullivanKenneth B Wells
Aug 7, 2008·American Journal of Epidemiology·Stephen R Cole, Miguel A Hernán
Nov 7, 2009·General Hospital Psychiatry·Jennifer Brennan BradenMichael Von Korff
Feb 13, 2010·Journal of Psychiatric Research·Maurice M Ohayon, Alan F Schatzberg
Mar 8, 2012·JAMA : the Journal of the American Medical Association·Karen H SealThomas C Neylan
Sep 11, 2012·General Hospital Psychiatry·Joseph O MerrillConstance Weisner
Oct 30, 2013·Journal of General Internal Medicine·Jeffrey F ScherrerPatrick J Lustman
Jun 27, 2014·BMC Psychiatry·Marloes M J G GerritsBrenda W Penninx
Jan 20, 2015·Pain·Jeffrey F ScherrerUNKNOWN Residency Research Network of Texas (RRNeT) Investigators
Jun 17, 2015·The Journal of Pain : Official Journal of the American Pain Society·Jenna GoeslingChad M Brummett

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Citations

Nov 5, 2016·Current Oncology Reports·Mellar P Davis, Zankhana Mehta
Apr 2, 2017·Journal of Psychiatric Research·Lisham AshrafiounWilfred R Pigeon
Apr 30, 2017·Current Opinion in Behavioral Sciences·Catherine M Cahill, Anna Mw Taylor
Feb 17, 2018·British Journal of Clinical Pharmacology·Samanta LalicJenni Ilomäki
Mar 6, 2018·The Clinical Journal of Pain·Mark D Sullivan
Jun 16, 2018·Pain·Graham MazereeuwDavid N Juurlink
Aug 11, 2016·F1000Research·Christopher J Evans, Catherine M Cahill
Jul 14, 2016·PM & R : the Journal of Injury, Function, and Rehabilitation·Ameet NagpalJaspal R Singh
May 5, 2018·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ariel M BariaChristine Miaskowski
Mar 12, 2019·Population Health Management·Sarah GebauerF David Schneider
Feb 14, 2018·The British Journal of Psychiatry : the Journal of Mental Science·Jeffrey F ScherrerPatrick J Lustman
Jul 25, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jessica C YoungNabarun Dasgupta
Aug 31, 2019·Molecular Psychiatry·Nolan R WilliamsAlan F Schatzberg
Aug 15, 2018·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Hanna Grol-Prokopczyk
Aug 9, 2016·Family Practice·Jeffrey F ScherrerPatrick J Lustman
Feb 6, 2019·Advances in Pharmacological Sciences·Mervin Chávez-CastilloJoselyn Rojas-Quintero
May 16, 2019·European Journal of Preventive Cardiology·Jeffrey F ScherrerPaula P Schnurr
May 6, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Mayank GuptaNebojsa Nick Knezevic
Apr 25, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Graham MazereeuwDavid N Juurlink
Jun 17, 2020·Journal of Psychiatry and Brain Science·Jeffrey F ScherrerSarah Skiold-Hanlin
May 10, 2018·Frontiers in Psychiatry·Amie L SeverinoWendy M Walwyn
Nov 23, 2016·Current Pain and Headache Reports·Daniel KrashinMark Sullivan
Jan 6, 2018·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Mark Sullivan
Oct 22, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Sarah T StahlJordan F Karp
Mar 24, 2016·Pharmacoepidemiology and Drug Safety·Jeffrey F ScherrerPatrick J Lustman
May 16, 2018·Health Services Research and Managerial Epidemiology·Muhamad Y ElrashidiJon O Ebbert
Aug 14, 2019·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Megan WildesMarian Wilson
Jan 31, 2021·Clinical Psychology Review·Andrew H RogersGordon J G Asmundson
Mar 7, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Marc O MartelRobert R Edwards
Mar 30, 2018·The Journal of Pain : Official Journal of the American Pain Society·Karen H SealUNKNOWN Chronic Effects of Neurotrauma Consortium Study Group
Oct 17, 2017·The Journal of Pain : Official Journal of the American Pain Society·Joanne SalasPatrick J Lustman
Sep 24, 2021·Brain and Behavior·Joseph Gregory Hobelmann, Andrew S Huhn

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