Increased risk of ischemic bowel complications during treatment with bevacizumab after pelvic irradiation: report of three cases

International Journal of Radiation Oncology, Biology, Physics
Florian LordickMario Sarbia

Abstract

To assess the rate of severe bowel complications during treatment with the anti-vascular endothelial growth factor monoclonal antibody bevacizumab. We performed a retrospective evaluation of bevacizumab-associated severe intestinal adverse events from our institutional database. A total of 33 patients started treatment with bevacizumab at our institution during the first 6 months after its approval in Germany. Three patients (9%) presented with severe bowel complications: two with acute ischemic colitis and one with gastrointestinal perforation with a fatal outcome. All 3 patients had undergone radiotherapy directed to the pelvis before treatment with bevacizumab. None of the 30 patients without bowel complications had been pretreated with infradiaphragmatic irradiation. Histologic evaluation of bowel biopsies and resection specimens revealed severe ischemic bowel damage as the pathophysiologic background of the clinical findings. This report contributes to the pathophysiologic clarification of bevacizumab-induced bowel complications and points to a potentially increased risk of severe ischemic damage during treatment with bevacizumab in patients who have undergone previous radiotherapy.

References

May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·B EmamiM Wesson
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
May 4, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fairooz F KabbinavarSomnath Sarkar

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Citations

Apr 25, 2007·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·K AbbrederisC Schuhmacher
Apr 25, 2007·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·F Lordick, J R Siewert
Sep 6, 2007·Cancer Metastasis Reviews·Richard J Epstein
Jul 31, 2008·Investigational New Drugs·Elisabeth SchellhaasUwe Pohlen
Apr 26, 2012·Current Oncology Reports·Taher Abu-HejlehThorvardur R Halfdanarson
Feb 2, 2013·Journal of Gastrointestinal Cancer·Andy BarnettCharles R Thomas
Jan 22, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J M Gasent BlesaS Martín Algarra
Mar 20, 2008·Nature Clinical Practice. Oncology·Yohann LoriotJean-Charles Soria
May 25, 2007·Nature Reviews. Cancer·Henk M W Verheul, Herbert M Pinedo
Feb 15, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E P HuiA T C Chan
Feb 1, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C BourgierE Deutsch
Jun 9, 2010·The Cancer Journal·Bruce D MinskyVincenzo Valentini
Jun 5, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ruud P M DingsRobert J Griffin
Dec 23, 2011·Radiation Oncology·Maximilian NiyaziClaus Belka
Jan 22, 2009·Annals of Surgical Oncology·Thierry BègeJean Robert Delpero
Jan 26, 2012·Clinical Ophthalmology·John ChristoforidisKrista La Perle
Mar 1, 2008·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Young Il ChoiSeong Hoon Shin
Oct 22, 2013·Radiation and Environmental Biophysics·Michael OrthClaus Belka
Jun 10, 2009·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Friederike MarquardtClaus Rödel
Mar 1, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M GeierH Geinitz
Aug 8, 2013·International Journal of Radiation Oncology, Biology, Physics·Brandon M BarneyKenneth R Olivier
Feb 11, 2012·Journal of the American College of Surgeons·Asvin M GanapathiChristopher R Mantyh
May 7, 2011·Cancer Treatment Reviews·Renaud MazeronEric Deutsch
Feb 13, 2010·Cirugía española·Carlos PlacerJose María Enríquez Navascués
Aug 22, 2009·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·R MazeronE Deutsch
Apr 7, 2009·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·O DiazC Carrie
Apr 7, 2009·Gastroentérologie Clinique Et Biologique·O BouchéS Lagarde
Mar 4, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pierre Sonveaux
Jan 30, 2008·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P MaingonG Truc
Feb 5, 2008·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·R MazeronE Deutsch
Sep 6, 2006·Gastroenterology Clinics of North America·Wolfram Goessling, Robert J Mayer
Oct 31, 2006·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C Hennequin
Jul 23, 2008·The Journal of Pharmacy and Pharmacology·Aoife M Shannon, Kaye J Williams
Dec 3, 2009·Journal of Surgical Oncology·Isabelle DeshaiesDominique Elias
Apr 4, 2013·Current Eye Research·John B ChristoforidisZhongfa Liu
Jun 13, 2015·International Journal of Radiation Oncology, Biology, Physics·Erqi L PollomDaniel T Chang
Mar 20, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Fairooz F KabbinavarAxel Grothey
Aug 27, 2013·Seminars in Oncology·Christian Kollmannsberger, Teresa Mitchell
Sep 12, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·D AntoniF Mornex

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