Increased risk of malignancy with adalimumab combination therapy, compared with monotherapy, for Crohn's disease

Gastroenterology
Mark T OstermanJames D Lewis

Abstract

Few studies have assessed the risk of malignancy from anti-tumor necrosis factor monotherapy or combination therapy for Crohn's disease (CD). We determined the relative risk of malignancy in patients with CD who received adalimumab monotherapy, compared with the general population. We also compared the risk of malignancy associated with combination adalimumab and immunomodulator therapy with that of adalimumab monotherapy. We performed a pooled analysis of data from 1594 patients with CD who participated in clinical trials of adalimumab (CLASSIC I and II, CHARM, GAIN, EXTEND, and ADHERE studies; 3050 patient-years of exposure). We calculated rates of malignancy among patients; the expected rates of malignancy, based on the general population, were derived from the Surveillance, Epidemiology, and End Results registry and National Cancer Institute survey. Compared with the general population, patients receiving adalimumab monotherapy did not have a greater than expected incidence of nonmelanoma skin cancer (NMSC) or other cancers, whereas those receiving combination therapy had a greater than expected incidence of malignancies other than NMSC (standardized incidence ratio, 3.04; 95% confidence interval [CI], 1.66-5.10) and of NMS...Continue Reading

References

Jul 20, 2002·Inflammatory Bowel Diseases·Jacques CosnesJean-Pierre Gendre
Apr 19, 2006·Gastroenterology·Marc LémannUNKNOWN Groupe d'Etude Therapeutique des Affections Inflammatoires du Tube Digestif (GETAID)
May 2, 2007·Annals of Internal Medicine·William J SandbornPaul F Pollack
Jun 14, 2008·Alimentary Pharmacology & Therapeutics·S HutflessL J Herrinton
Jun 14, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Laurent Peyrin-BirouletJean-Frédéric Colombel
Jun 30, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Corey A SiegelBruce E Sands
Dec 17, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Millie D LongMichael D Kappelman
Mar 20, 2010·Alimentary Pharmacology & Therapeutics·R PanaccioneP F Pollack
Apr 16, 2010·The New England Journal of Medicine·Jean Frédéric ColombelUNKNOWN SONIC Study Group
Oct 5, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David S KotlyarGary R Lichtenstein
Feb 8, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Fiona D M van SchaikBas Oldenburg
Jun 8, 2011·Alimentary Pharmacology & Therapeutics·M A KammA M Robinson
Jun 29, 2011·Gastroenterology·Laurent Peyrin-BirouletUNKNOWN Cesame Study Group
Aug 3, 2011·Gastroenterology·Harminder SinghCharles N Bernstein
Oct 28, 2011·The American Journal of Gastroenterology·Lisa J HerrintonJames E Allison
May 16, 2012·Gastroenterology·Millie D LongMichael D Kappelman
Oct 12, 2012·Arthritis and Rheumatism·Kevin HaynesUNKNOWN SABER Collaboration
Nov 13, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Marine CamusJacques Cosnes
Mar 22, 2013·American Journal of Epidemiology·Björn PasternakAnders Hviid

❮ Previous
Next ❯

Citations

Jul 13, 2014·American Journal of Clinical Dermatology·Lauren BrinJerry D Brewer
Aug 12, 2014·Gastroenterology Clinics of North America·Parambir S Dulai, Corey A Siegel
Aug 12, 2014·Gastroenterology Clinics of North America·Parambir S DulaiLaurent Peyrin-Biroulet
Dec 19, 2015·Expert Review of Clinical Pharmacology·A S StrikM Löwenberg
Apr 29, 2015·Expert Review of Gastroenterology & Hepatology·Rimma Goldberg, Peter M Irving
Oct 24, 2014·Expert Review of Clinical Immunology·Jeffrey S Hyams
Dec 1, 2015·Expert Opinion on Investigational Drugs·Marc Berns, Daniel W Hommes
Aug 10, 2015·Clinical Pharmacokinetics·Mehmet CoskunOle Haagen Nielsen
Jan 23, 2016·Expert Opinion on Drug Safety·Konstantinos PapamichaelLaurent Peyrin-Biroulet
Dec 4, 2015·Gastroenterology·Franck CarbonnelUNKNOWN Groupe d'Étude Thérapeutique des Affections Inflammatoires Digestives
Oct 2, 2015·European Journal of Gastroenterology & Hepatology·Eleni VolonakiMamoun Elawad
Aug 22, 2015·Journal of Crohn's & Colitis·Vito AnneseUNKNOWN ECCO
Mar 1, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mark T OstermanJames D Lewis
Mar 10, 2015·Gastroenterology·Brian BresslerUNKNOWN Toronto Ulcerative Colitis Consensus Group
Mar 5, 2016·Journal of Crohn's & Colitis·Livia BianconeUNKNOWN Italian Group for the study of Inflammatory Bowel Disease
Sep 12, 2015·Journal of Internal Medicine·P Malmborg, H Hildebrand
Jun 4, 2015·Current Opinion in Gastroenterology·Paula Sousa, Matthieu Allez
Apr 18, 2015·International Journal of Surgery Case Reports·Ioannis PapaconstantinouIoannis E Koutroubakis
Feb 18, 2015·Journal of Crohn's & Colitis·Alicia AlgabaFernando Bermejo
Mar 31, 2015·Journal of Crohn's & Colitis·Thibaut Vaysse, Franck Carbonnel
Dec 30, 2014·Lancet·Ashwin N Ananthakrishnan
Jun 11, 2014·Best Practice & Research. Clinical Gastroenterology·Ophélie AntunesLaurent Peyrin-Biroulet
Aug 15, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Frank I ScottJames D Lewis
Dec 30, 2014·Inflammatory Bowel Diseases·Livia BianconeFrancesco Pallone
Sep 25, 2014·Inflammatory Bowel Diseases·Richard S KalmanFrancis A Farraye
Mar 16, 2016·Inflammatory Bowel Diseases·Xavier RoblinLaurent Peyrin-Biroulet
May 7, 2016·Current Opinion in Gastroenterology·Sushil K Garg, Edward V Loftus
Jul 21, 2016·Pediatric Gastroenterology, Hepatology & Nutrition·Won Jae SongYon Ho Choe
Jul 16, 2016·Canadian Journal of Microbiology·Jessica D ForbesCharles N Bernstein
Jul 28, 2016·Expert Opinion on Drug Safety·Tommaso GabbaniVito Annese
Jul 29, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Edward V LoftusGordana Kosutic
Sep 8, 2016·European Journal of Gastroenterology & Hepatology·Lucas WautersMarc Ferrante
Jan 31, 2017·Expert Opinion on Biological Therapy·Simon Hirschmann, Markus F Neurath
Feb 1, 2017·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Chang Hwan ChoiUNKNOWN IBD Study Group of the Korean Association for the Study of the Intestinal Diseases
Mar 21, 2017·Expert Opinion on Biological Therapy·Miles P Sparrow

❮ Previous
Next ❯

Related Concepts

Related Feeds

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Bowen's Disease

Bowen's disease is thought of as an easily-treatable early stage of skin cancer, characterized by red, scaly patches on the skin. Discover the latest research on Bowen's disease here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Mark T OstermanJames D Lewis
World Journal of Gastrointestinal Pharmacology and Therapeutics
Sameer GaggarNicholas Thompson
© 2021 Meta ULC. All rights reserved