Increased risk of ovarian hyperstimulation syndrome following controlled ovarian hyperstimulation in patients with vascular endothelial growth factor +405 cc genotype

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Hans Ivar HanevikJarl A Kahn

Abstract

Ovarian hyperstimulation syndrome (OHSS) is a serious complication following controlled ovarian hyperstimulation (COH) for in vitro fertilization. OHSS has a range of clinical features from mild abdominal distention to severe thromboembolic events. Several clinical manifestations of OHSS such as ascites and hemoconcentration can be attributed to increased vascular permeability. Vascular endothelial growth factor (VEGF) and its receptor VEGFR2 have been identified as an important signaling system in mediating this increase. There is considerable genetic variation in the VEGF/R2 signaling system. We present the first study to examine if single nucleotide polymorphisms (SNPs) in the genes encoding the VEGF/R2 signaling system are associated with OHSS following COH. Blood samples from 53 OHSS patients and 100 controls were analyzed for six SNPs of interest. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by a multivariate logistic regression model. We found an association between the VEGF +405cc genotype and OHSS (OR 3.4, 95% CI 1.01-11.7). This finding requires confirmation from other patient populations.

References

Apr 1, 1990·Controlled Clinical Trials·W D Dupont, W D Plummer
Jan 11, 2000·Nucleic Acids Research·S T SherryK Sirotkin
Aug 6, 2004·Endocrine Reviews·Napoleone Ferrara
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Oct 28, 2005·Genome Research·Gudmundur A ThorissonLincoln D Stein
Mar 7, 2006·Molecular Human Reproduction·Ilona BányászJános Rigó
Aug 21, 2007·Journal of the American College of Cardiology·Yibo WangRutai Hui
Nov 6, 2007·Human Reproduction·Davide GentiliniAnna Maria Di Blasio
Feb 15, 2011·Reproductive Biomedicine Online·Jeroen van DisseldorpBart Fauser
May 14, 2011·Reproductive Biomedicine Online·Hans Ivar HanevikJarl A Kahn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.