Increased risk of periodontitis among patients with Crohn's disease: a population-based matched-cohort study

International Journal of Colorectal Disease
Ying-Chen ChiChyi-Huey Bai

Abstract

Periodontitis is a frequently cited extraintestinal manifestation of Crohn's disease (CD). Despite a plethora of investigations and a recent meta-analysis linking CD and periodontitis, no study has estimated the risk of periodontitis among CD patients with respect to a comparison group nor has any investigation analyzed the effect of CD-specific medications on the risk of periodontitis. The present cohort study compared CD patients and matched subjects without a history of inflammatory bowel disease (IBD) to estimate the effect of CD and CD-specific pharmaceutical prescriptions on the risk of developing periodontitis by leveraging a population-based dataset in Taiwan. We sourced 6657 CD patients and 26,628 comparison subjects without a history of IBD from the Taiwan National Health Insurance Database. Cox proportional hazards regressions were used to estimate the risk of subsequent periodontitis by CD status and pharmaceutical prescription during the follow-up period. After adjusting for socioeconomic status (SES), urbanicity, selected medical co-morbidities, and CD-specific pharmaceutical prescriptions, the hazard ratio (HR) for subsequent periodontitis among patients with CD was 1.36 (95% CI = 1.25-1.48) that of comparison su...Continue Reading

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Citations

Jul 13, 2019·International Journal of Molecular Sciences·Kübra Bunte, Thomas Beikler
Mar 14, 2020·BMC Oral Health·Yang-Yang SheSi-Lian Fang
Oct 23, 2020·World Journal of Gastroenterology : WJG·Eun Ae KangJoo Sung Kim
Jul 7, 2021·Expert Review of Gastroenterology & Hepatology·Kevimy AgossaMathurin Fumery

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