Increased risk of pulmonary tuberculosis in patients with previous non-tuberculous mycobacterial disease

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
S-C HsingJ-J Wang


To investigate whether or not there is an increased risk of pulmonary tuberculosis (PTB) after non-tuberculous mycobacterial (NTM) disease. A retrospective cohort study of 212 NTM patients and 4240 control cases. Patients with previous NTM disease had a significantly higher incidence of PTB than controls (incidence rate ratio [IRR] 14.74, 95%CI 8.71-24.94, P < 0.0001). Cox's proportional hazards analysis yielded an adjusted hazards ratio (aHR) of 10.15 (95%CI 5.67-18.17, P < 0.05) for NTM-associated PTB. The majority of the PTB cases (17/23, 73.9%) were diagnosed within 6 months after the diagnosis of NTM disease. Older age (≥65 years, aHR 4.45, 95%CI 1.94-10.22, P < 0.05), male sex (aHR 1.75, 95%CI 1.01-3.13, P < 0.05), human immunodeficiency virus (HIV) infection (aHR 12.49, 95%CI 3.20-48.79, P < 0.05) and chronic obstructive pulmonary disease (aHR 4.46, 95%CI 2.19-9.10, P < 0.05) were independent risk factors for developing PTB after NTM disease. The cumulative incidence of PTB in patients with previous NTM disease was significantly higher than in controls (P < 0.0001, Kaplan-Meier analysis). However, there was no significant difference in the survival rates in the two cohorts. Increased PTB prevalence after NTM disease was ...Continue Reading


Mar 25, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Man Wah YeungBeate Sander

Related Concepts

Atypical Mycobacterial Infection, Disseminated
Retrospective Studies
Tuberculosis, Pulmonary
Incidence Studies
HIV Infections
Cox Proportional Hazards Models
Genus Mycobacterium
Retrospective Cohort Study

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