Increased risk of smoking-related illnesses in schizophrenia patients: A nationwide cohort study

Schizophrenia Research
Israel KriegerDaniel Feingold

Abstract

Schizophrenia patients smoke at three times the rate of the general population, and are more susceptible to smoking-related illnesses. The goal of the current study was to evaluate the cumulative probability of chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IHD) following first documentation of smoking among schizophrenia patients as compared to smoking healthy controls. A nationally representative cohort study was designed to assess the odds and cumulative probability of COPD and IHD among individuals with schizophrenia (n = 10,502) and a matched-sample of smoking healthy controls (n = 10,502). Hierarchical logistic regressions and Kaplan-Meier regression models were used to compare odds and cumulative probabilities across the two groups. After adjusting for clinical and demographic factors, smoking schizophrenia patients had a higher probability of receiving a diagnosis of COPD than smoking healthy controls (OR 2.14, 95%CI 1.51-3.01, p < 0.001). The probability of having COPD increased more rapidly in smoking schizophrenia patients, yet the opposite trajectory prevailed for IHD, showing a decreased cumulative probability in smoking schizophrenia patients compared to smoking healthy controls. Schizoph...Continue Reading

Citations

Feb 27, 2021·European Psychiatry : the Journal of the Association of European Psychiatrists·M J Jaen-MorenoF Sarramea
Jul 10, 2021·Journal of Autism and Developmental Disorders·Israel KriegerDana Tzur Bitan

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