PMID: 9192937Jun 1, 1997Paper

Increased risk of tuberculosis transmission in families with microepidemics

The European Respiratory Journal
R VidalF Morell

Abstract

In the present study, we analysed: 1) prevalence of TB infection and incidence of disease among family contacts of a cohort of patients with TB; 2) differential characteristics of families with microepidemics and families with < or = 1 new case of TB; and 3) efficacy of chemoprophylaxis in this group of contacts. Three thousand and seventy one family contacts of 635 patients with TB were studied. The study consisted of tuberculin skin testing and chest radiography in all cases, and bacteriological studies when active disease was suspected. Contacts were classified as belonging to: families with microepidemics (FME) (those with > or = 2 new cases of TB); families with one new case; and families with with no new cases. Chemoprophylaxis was prescribed in contacts following standard recommendations; all were followed up for 12-18 months. Rates of TB infection and disease among families, as well as the incidence of TB disease between those compliant and noncompliant with chemoprophylaxis were compared. Among the 3,071 contacts, 1,264 (41%) were infected and 176 (6%) had TB. Twenty two families with FME (3%) yielded 55 new cases of TB. The prevalence of infection (excluding the TB cases) was 80% in families with FME, 52% in families ...Continue Reading

Citations

Nov 26, 1999·The Pediatric Infectious Disease Journal·K SorenD J McMahon
Aug 19, 2005·Medicinski pregled·Vesna Skodrić-Trifunović
Feb 14, 2012·The Journal of Infection·Ewa Augustynowicz-KopećZofia Zwolska
Mar 1, 2011·Enfermedades infecciosas y microbiología clínica·Alfredo TagarroAlfonso Cañete
Mar 1, 2011·Gaceta sanitaria·María del Carmen Álvarez-CastilloDionisio Herrera

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