Increased risks of psychiatric disorders in patients with primary Sjögren's syndrome-a secondary cohort analysis of nationwide, population-based health claim data

Clinical Rheumatology
Min-Chih HsiehMalcolm Koo

Abstract

Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune disease. The aim of this study was to investigate the risk of five common psychiatrist-diagnosed disorders in patients with pSS. Using Taiwan's National Health Insurance Research Database, 688 patients with newly diagnosed pSS between 2000 and 2012 were identified. Two comparison cohorts were assembled, namely, 3440 patients without pSS and 1302 newly diagnosed patients with rheumatoid arthritis. The incidences of depressive disorder, anxiety disorder, bipolar disorder, sleep disorder, and schizophrenia between the pSS cohort and the comparison cohorts were compared using Poisson regression models. Patients with pSS exhibited a significantly higher risk of developing depressive disorder (adjusted incidence rate ratio [aIRR] = 2.11, p < 0.001), anxiety disorder (aIRR = 2.20, p < 0.001), and sleep disorder (aIRR = 1.76, p = 0.012) when compared with the non-pSS cohort. The risks of developing depressive, anxiety, and sleep disorders were also significantly increased when compared to the rheumatoid arthritis comparison cohort. When the analyses were stratified by sex, depressive disorder (aIRR = 2.10, p < 0.001), anxiety disorder (aIRR = 2.02, p = 0.001), and sleep ...Continue Reading

References

Mar 16, 2000·Nuclear Medicine Communications·P LassP Lyczak
May 15, 2002·Annals of the Rheumatic Diseases·C VitaliUNKNOWN European Study Group on Classification Criteria for Sjögren's Syndrome
Jul 26, 2005·Lancet·Robert I Fox
Mar 4, 2006·The American Journal of Psychiatry·William W EatonPreben Bo Mortensen
Jun 30, 2009·Annals of the Rheumatic Diseases·Raphaèle SerorUNKNOWN EULAR Sjögren's Task Force
Apr 3, 2010·The Journal of Rheumatology·Jiunn-Horng Kang, Herng-Ching Lin
Jan 18, 2011·The Journal of Rheumatology·Meng-Yu WengTsung-Hsueh Lu
Feb 25, 2011·Annals of the Rheumatic Diseases·Raphaèle SerorUNKNOWN EULAR Sjögren's Task Force
Mar 22, 2013·Annual Review of Public Health·Ronald C Kessler, Evelyn J Bromet
Mar 21, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marja PertovaaraPia Isomäki
Apr 5, 2016·Neuropsychiatric Disease and Treatment·Ching-En Lin
Nov 20, 2016·The Lancet. Psychiatry·Christine Kuehner
Jun 18, 2017·Psychology, Health & Medicine·Yafei CuiBiyu Shen
Nov 20, 2018·Lupus·S J Bowman
Dec 14, 2018·International Journal of Molecular Sciences·Fabíola Reis de OliveiraEduardo Melani Rocha
Feb 6, 2019·Psychiatry and Clinical Neurosciences·Bogna Grygiel-GórniakMariusz Puszczewicz

❮ Previous
Next ❯

Citations

Dec 29, 2020·Frontiers in Medicine·Francesca IngegnoliRoberto Caporali

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.