Increased Risks of Spontaneous Bacterial Peritonitis and Interstitial Lung Disease in Primary Biliary Cirrhosis Patients With Concomitant Sjögren Syndrome

Medicine
Chun-Ting ChenHeng-Cheng Chu

Abstract

The incidence of Sjögren syndrome (SS) in primary biliary cirrhosis (PBC) patients is high. The influence of SS on the clinical outcomes of PBC patients, however, remains unclear. Our study retrospectively collected data on PBC-only patients and PBC patients with concomitant SS (PBC-SS) to compare the clinical differences of long-term outcomes between them.A total of 183 patients were diagnosed with PBC from January 1999 to December 2014 at our hospital. Of these, the authors excluded patients with diabetes, hypertension, advanced liver cirrhosis at initial diagnosis of PBC (Child-Turcotte-Pugh classification score of ≥7) and other liver diseases (ie, alcoholic liver disease, alpha-antitrypsin deficiency, viral hepatitis, and primary sclerosing cholangitis), and autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Of the remaining 125 patients, 77 (61.6%) were PBC-only and 48 (38.4%) were PBC-SS patients.The mean follow-up duration was 8.76 years. During the observation period, the incidence of interstitial lung disease was higher in the PBC-SS group than in the PBC-only group (P = 0.005). The occurrence of spontaneous bacterial peritonitis was significantly different in PBC-SS patients than in PBC...Continue Reading

References

Sep 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J LlachJ Rodés
Dec 1, 1991·British Journal of Rheumatology·C A KellyI D Griffiths
Jan 1, 1991·Scandinavian Journal of Rheumatology·C VitaliS Bombardieri
Jan 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L TitóJ Rodés
May 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B A Runyon
Aug 1, 1987·Journal of Clinical Gastroenterology·J G WallaceF P Quismorio
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B A RunyonF A Wyle
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A RimolaJ Rodes
Nov 1, 1995·The American Journal of Medicine·B PérezD Alarcón-Segovia
Aug 1, 1994·The American Journal of Medicine·M BhuvaD Jensen
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E J Heathcote
Sep 8, 2000·Annals of the Rheumatic Diseases·B K DavidsonI D Griffiths
Dec 6, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·N BossiniR Maiorca
May 23, 2002·Gastroenterology·Alex S Befeler, Adrian M Di Bisceglie
Sep 24, 2005·The New England Journal of Medicine·Marshall M Kaplan, M Eric Gershwin
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Eric GershwinUNKNOWN USA PBC Epidemiology Group
Jun 15, 2007·Clinical Rheumatology·Luis J JaraManuel Ramos-Casals
Jan 9, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shinji ShimodaM Eric Gershwin
Feb 28, 2009·Journal of Clinical Gastroenterology·Min ShenXuan Zhang
Apr 3, 2010·The Journal of Rheumatology·Jiunn-Horng Kang, Herng-Ching Lin
May 5, 2010·Advances in Chronic Kidney Disease·Laura C PlantingaNeil R Powe
Nov 19, 2010·European Journal of Gastroenterology & Hepatology·Hyun Chin ChoJoon Hyeok Lee
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Jun 15, 2012·Journal of Autoimmunity·Clio P MavraganiHaralampos M Moutsopoulos
Dec 19, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeffrey R GarberUNKNOWN American Association of Clinical Endocrinologists and American Thyroid Association Taskforce on Hypothyroidism in Adults
Jul 25, 2013·Journal of the Chinese Medical Association : JCMA·Chen-Jung ChangShou-Dong Lee
Nov 11, 2014·Expert Review of Clinical Immunology·Ahmad H AliKeith D Lindor

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Citations

Dec 14, 2016·World Journal of Hepatology·Ying-Qiu Huang
Aug 4, 2020·Digestive Diseases and Sciences·Yamini NatarajanFasiha Kanwal
Sep 30, 2021·Clinical Reviews in Allergy & Immunology·Francesca ColapietroElena Generali

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

SPSS

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