Increased RNA and heme synthesis in mouse erythroid precursors by parathyroid hormone

Acta Haematologica
J LeviM Djaldetti

Abstract

The in vitro effect of parathyroid hormone (PTH) on RNA and heme synthesis by embryonic mouse liver erythroid precursors was examined. PTH produced a dose-dependent effect on RNA synthesis. A maximal increase of 60 +/- 16% (p less than 0.02) was observed with 1.0 U PTH/ml, whereas with higher concentrations a significant decline was found. Furthermore, PTH stimulated heme synthesis after 24 h of incubation. The maximal enhancement of 32 +/- 7% (p less than 0.01) was observed with 0.5 U PTH/ml, a lower effect was obtained with 1.0 U PTH/ml, while 2.0 U PTH/ml caused a pronounced decrease of heme synthesis. These data indicate that PTH affects directly the erythroid precursors by a mechanism similar to that of erythropoietin. The inhibitory effect on the RNA synthesis observed with large doses of PTH may explain at least one of the causes of the anemia reported in patients with primary hyperparathyroidism.

Citations

Jul 1, 1983·Calcified Tissue International·M J AtkinsonR D Hesch
Jan 1, 1981·Veterinary Clinical Pathology·J R Easley
May 1, 1981·The Journal of Clinical Investigation·D MeytesS G Massry
Apr 1, 1982·The Journal of Clinical Investigation·E BoginJ Smith
Feb 1, 1982·American Journal of Hematology·T J ConnellyR Silver

Related Concepts

Metazoa
SDS-PAGE
Pronormoblasts
Erythrocytes
Erythropoiesis
Heme
Liver
Mice, Inbred C57BL
Parathyroid Hormone Peptide (1-34)
RNA

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