Increased S100B serum levels in schizophrenic patients with tardive dyskinesia: association with dyskinetic movements

Journal of Psychiatric Research
Xiang Yang ZhangThomas R Kosten

Abstract

Several studies show that calcium-binding protein S100B is increased in schizophrenia and may be involved in the pathogenesis of tardive dyskinesia (TD). We therefore compared serum S100B levels in normal controls (n=60), schizophrenic patients with (n=32) and without TD (n=50). Assessments included the abnormal involuntary movement scale (AIMS) and the positive and negative syndrome scale (PANSS). Serum S100B levels were measured by enzyme-linked immunosorbent assay (ELISA). The results indicated that patients with TD had higher serum S100B levels than normals and those without TD. Serum S100B levels were positively correlated with AIMS scores in patients with TD. These data suggest that increased S100B levels may be related to neuro-degeneration, associated with TD pathophysiology.

References

Dec 1, 1991·Archives of General Psychiatry·J B Lohr
Apr 1, 1982·Archives of General Psychiatry·N R Schooler, J M Kane
Jun 5, 1999·Biological Psychiatry·M WiesmannH Kirchner
Apr 5, 2001·Journal of Psychiatric Research·D R LaraD O Souza
Dec 7, 2002·CNS Drugs·James B LohrAlexander B Niculescu
Mar 20, 2003·Microscopy Research and Technique·Matthias RothermundtVolker Arolt
Jun 26, 2003·The Journal of Clinical Psychiatry·Scott W Woods
Jul 3, 2003·Schizophrenia Research·Matthias L SchroeterIngolf E Blasig
Mar 5, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthias RothermundtVolker Arolt
Jul 9, 2004·Molecular Psychiatry·M RothermundtV Arolt
Jan 27, 2005·Biochemical and Biophysical Research Communications·Jixia LiuLin He
Mar 21, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Nico J M van BeverenDurk Fekkes
Nov 4, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Matthias RothermundtBettina Pfleiderer
Feb 7, 2007·Current Opinion in Psychiatry·Gary Remington
Apr 27, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Asli SarandolEmre Sarandol
Jan 19, 2008·Pharmacopsychiatry·Y-L TangP B Mitchell
Mar 12, 2008·Current Opinion in Psychiatry·Christoph U Correll, Eva M Schenk
Mar 28, 2008·Acta Neuropathologica·Jeanne E BellHans Kretzschmar
Aug 23, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Anya PedersenMatthias Rothermundt
Sep 9, 2008·Acta Neuropathologica·Andrea SchmittPeter Falkai
Mar 31, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Christa HohoffMatthias Rothermundt

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Citations

May 9, 2014·Neurotoxicity Research·Trevor ArcherMax Rapp Ricciardi
May 28, 2013·BMC Psychiatry·Kara O'ConnellKumlesh K Dev
Sep 4, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Lukasz BojarskiUrszula Wojda
Mar 5, 2016·Frontiers in Cellular Neuroscience·Katharina SchümbergMatthias L Schroeter
Feb 27, 2013·Psychiatry and Clinical Neurosciences·Silvia Yelmo-CruzPedro Abreu-González
Jul 6, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Li TianXiang Yang Zhang
Sep 10, 2014·PloS One·Katina AleksovskaAlessandra Frustaci
Apr 25, 2017·The Psychiatric Quarterly·Huiqiong DengOlaoluwa O Okusaga
Jan 8, 2019·Psychiatry Research·Elżbieta KozłowskaEwa Brzezińska-Błaszczyk

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